Isotryptamine, also known as 2-(1-indolyl)ethylamine, is a
chemical compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element ...
and
positional isomer
In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is a compound that contains the same number and type of atoms, but with a different connectivity (i.e. arrangement of bonds) between them. The ...
of
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...
(2-(3-indolyl)ethylamine).
A variety of isotryptamine
derivative
In mathematics, the derivative is a fundamental tool that quantifies the sensitivity to change of a function's output with respect to its input. The derivative of a function of a single variable at a chosen input value, when it exists, is t ...
s, or
substituted
Substitution may refer to:
Arts and media
*Substitution (poetry), a variation in poetic scansion
*Substitution (theatre), an acting methodology
Music
*Chord substitution, swapping one chord for a related one within a chord progression
*Tritone ...
isotryptamines, have been developed, including
serotonergic psychedelic
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...
s and
psychoplastogen
Psychoplastogens, also known as neuroplastogens, are a group of Small molecule#Drugs, small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single admin ...
s like
6-MeO-isoDMT;
non-hallucinogenic psychoplastogens like
isoDMT,
5-MeO-isoDMT, and
zalsupindole (DLX-001; AAZ-A-154);
serotonin
5-HT2C receptor agonists like
(''S'')-5,6-difluoro-isoAMT,
Ro60-0175
Ro60-0175, also known as (''S'')-5,6-difluoroindolmethylethylamine, is a serotonin receptor agonist of the isotryptamine group developed by Hoffmann–La Roche, which has applications in scientific research.
It acts as a potent and selective ...
((''S'')-5-fluoro-6-chloro-isoAMT), and
PNU-181731;
serotonin
5-HT6 receptor modulator
Signal modulation is the process of varying one or more properties of a periodic waveform in electronics and telecommunication for the purpose of transmitting information.
The process encodes information in form of the modulation or message ...
s;
and dual
monoamine releasing agent
A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of one or more monoamine neurotransmitters from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrati ...
s and
serotonin receptor agonist
A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of t ...
s like
isoAMT (PAL-569).
is the isotryptamine analogue of
LSD
Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. I ...
and may be considered a
cyclized isotryptamine.
References
Serotonin receptor modulators
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