Interstate 280 may refer to multiple highways, all of which are or were related to
Interstate 80
Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the ori ...
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Interstate 280 (California)
Interstate 280 (I-280) is a major north–south auxiliary Interstate Highway in the San Francisco Bay Area of Northern California. It runs from I-680 and US Route 101 (US 101) in San Jose to King and 5th streets in San Franci ...
, a north–south freeway running from San Jose to San Francisco
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Interstate 280 (Iowa–Illinois), part of the beltway around the Quad Cities
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Interstate 280 (New Jersey), a connector from Interstate 80 to Interstate 95 in Newark
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Interstate 280 (Ohio), a connector in Toledo from Interstates 80/90 to Interstate 75
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Interstate 276, once designated as I-280 when I-76 was I-80S
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Interstate 680 (Nebraska–Iowa)
Interstate 680 (I-680) in Nebraska and Iowa is the northern bypass of the Omaha–Council Bluffs metropolitan area. I-680 spans from its southern end in western Omaha, Nebraska, to its eastern end near Crescent, Iowa. The freeway passes ...
, once designated as I-280
{{Road disambiguation
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