ICI-204,448
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ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid
agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
, with possible uses in the treatment of
heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...
as well as anti-
itching An itch (also known as pruritus) is a sensation that causes a strong desire or reflex to scratch. Itches have resisted many attempts to be classified as any one type of sensory experience. Itches have many similarities to pain, and while both ...
effects. It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.


References

Synthetic opioids Chloroarenes Acetamides 1-Pyrrolidinyl compounds Kappa-opioid receptor agonists Phenol ethers Acetic acids Peripherally selective drugs {{analgesic-stub