The Holin superfamily VII is a
superfamily of integral
membrane transport protein
A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembra ...
s. It is one of the seven different
holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.
The Holin superfamily VII includes one TC family:
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The Mycobacterial 2 TMS Phage Holin (M2 Hol) Family
Superfamily VII consists of famil
TC# 1.E.36 which has six subfamilies, all distantly related to each other. Reddy and Saier (2013) found that there was also some indication that this family could possibly be related to the SPP1 Holin family
TC# 1.E.31 and the 2/3 Holin family
TC# 1.E.33.
These three families share the characteristics that they consist of members that are of about the same sizes and have 2 transmembrane segments (TMSs). There is however an exception; subfamily 6
TC# 1.E.36.6 includes proteins displaying 4 putative TMSs.
See also
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Holin
Holins are a diverse group of small proteins produced by dsDNA bacteriophages in order to trigger and control the degradation of the host's cell wall at the end of the lytic cycle. Holins form pores in the host's cell membrane, allowing lysins t ...
*
Lysin
Lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic cycle. Lysins are highly evolved enzymes that are able to targ ...
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Transporter Classification Database
References
Holins
Protein superfamilies
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