statistical genetics Statistical genetics is a scientific field concerned with the development and application of statistical methods for drawing inferences from genetic data. The term is most commonly used in the context of human genetics. Research in statistical gen ...

, Haseman–Elston (HE) regression is a form of

statistical regression Statistics (from German: ''Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industri ...

originally proposed for

linkage analysis Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Two genetic markers that are physically near to each other are unlikely to be separ ...

quantitative trait Complex traits, also known as quantitative traits, are traits that do not behave according to simple Mendelian inheritance laws. More specifically, their inheritance cannot be explained by the genetic segregation of a single gene. Such traits show ...

s for sibling pairs. It was first developed by Joseph K. Haseman and Robert C. Elston in 1972. A much earlier source of sib-pair linkage implementation was, in 1935 and 1938, proposed by Lionel S. Penrose, who is father of Nobel laureate theoretical physicist

Roger Penrose Sir Roger Penrose (born 8 August 1931) is an English mathematician, mathematical physicist, philosopher of science and Nobel Laureate in Physics. He is Emeritus Rouse Ball Professor of Mathematics in the University of Oxford, an emeritus fello ...

. In 2000, Elston et al. proposed a "revisited", extended form of Haseman–Elston regression. Since then, further extensions to the "revisited" form of HE regression have been proposed. Although HE regression "...seems a rusty weapon in the

genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...

analysis armory of the

GWAS In genomics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of Single-nucleotide polymorphism, genetic variants in different i ...

era. This is because the HE regression relies on relatedness measured on IBD but not

identity by state A DNA segment is identical by state (IBS) in two or more individuals if they have identical nucleotide sequences in this segment. An IBS segment is identical by descent (IBD) in two or more individuals if they have inherited it from a common an ...

(IBS)...", HE has been adapted for association analysis in unrelated samples, whose relatedness is measured in IBS.

References

Regression analysis Statistical genetics Genetic linkage analysis {{Genetics-stub