Günter Blobel (; May 21, 1936 – February 18, 2018) was a

Silesia Silesia (see names #Etymology, below) is a historical region of Central Europe that lies mostly within Poland, with small parts in the Czech Silesia, Czech Republic and Germany. Its area is approximately , and the population is estimated at 8, ...

n German and American

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter ...

and 1999

Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...

laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in the cell.

Education and early life

Günter Blobel was born in Waltersdorf in the Prussian

Province of Lower Silesia The Province of Lower Silesia (; Silesian German: ''Provinz Niederschläsing''; ; ) was a province of the Free State of Prussia from 1919 to 1945. Between 1938 and 1941 it was reunited with Upper Silesia as the Province of Silesia. The capita ...

, then located in eastern Germany. In January 1945 his family fled from native Silesia to

Dresden Dresden (; ; Upper Saxon German, Upper Saxon: ''Dräsdn''; , ) is the capital city of the States of Germany, German state of Saxony and its second most populous city after Leipzig. It is the List of cities in Germany by population, 12th most p ...

to escape from the advancing

Red Army The Workers' and Peasants' Red Army, often shortened to the Red Army, was the army and air force of the Russian Soviet Republic and, from 1922, the Soviet Union. The army was established in January 1918 by a decree of the Council of People ...

. During the bombing of Dresden, Blobel, then 8, stayed with his family at a relative's farm to the west of the city. After the war, Blobel grew up and attended gymnasium in the

Saxon The Saxons, sometimes called the Old Saxons or Continental Saxons, were a Germanic people of early medieval "Old" Saxony () which became a Carolingian " stem duchy" in 804, in what is now northern Germany. Many of their neighbours were, like th ...

town of

Freiberg Freiberg () is a university and former mining town in Saxony, Germany, with around 41,000 inhabitants. The city lies in the foreland of the Ore Mountains, in the Saxon urbanization axis, which runs along the northern edge of the Elster and ...

. He studied medicine and graduated from the

University of Tübingen The University of Tübingen, officially the Eberhard Karl University of Tübingen (; ), is a public research university located in the city of Tübingen, Baden-Württemberg, Germany. The University of Tübingen is one of eleven German Excellenc ...

in 1960. After two years service in a medical internship, he moved to Madison, Wisconsin, following an older brother, enrolling in the

University of Wisconsin–Madison The University of Wisconsin–Madison (University of Wisconsin, Wisconsin, UW, UW–Madison, or simply Madison) is a public land-grant research university in Madison, Wisconsin, United States. It was founded in 1848 when Wisconsin achieved st ...

and, joining the lab of Van R. Potter for his graduate work. Blobel matriculated in 1967 with a Ph.D. He then moved to Rockefeller University as a postdoctoral fellow with George Palade, and was soon appointed as a professor.

Career and research

Blobel was appointed to the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

in 1986. Blobel was the sole recipient of the 1999

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...

for the discovery of signal peptides. Signal peptides form an integral part of

protein targeting Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. Proteins can be targeted to the inner space of an organelle, different intracellular m ...

, a mechanism for cells to direct newly synthesized

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

molecules to their proper location by means of an "address tag" (i.e., a signal peptide) within the molecule. Blobel died of cancer in

Manhattan Manhattan ( ) is the most densely populated and geographically smallest of the Boroughs of New York City, five boroughs of New York City. Coextensive with New York County, Manhattan is the County statistics of the United States#Smallest, larg ...

at New York-Presbyterian Weill Cornell Medical Center on February 18, 2018 at the age of 81. By the time of his death, Blobel was described as having "ushered cell biology into the molecular age" through his work on the fractionation and reconstitution of functional protein complexes and sub-cellular components ''in vitro''.

Philanthropy

Blobel became well known for his direct and active support for the rebuilding of

Germany Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...

, becoming, in 1994, the founder and president of the nonprofit "Friends of Dresden, Inc." He donated all of the Nobel award money to the restoration of Dresden, in particular for the rebuilding of the Frauenkirche (completed in 2005) and the building of a new

synagogue A synagogue, also called a shul or a temple, is a place of worship for Jews and Samaritans. It is a place for prayer (the main sanctuary and sometimes smaller chapels) where Jews attend religious services or special ceremonies such as wed ...

. In Leipzig he pursued a rebuilding of the Paulinerkirche, the university church of the

University of Leipzig Leipzig University (), in Leipzig in Saxony, Germany, is one of the world's oldest universities and the second-oldest university (by consecutive years of existence) in Germany. The university was founded on 2 December 1409 by Frederick I, Electo ...

, which had been blown up by the communist regime of East Germany in 1968, arguing "this is a shrine of German cultural history, connected to the most important names in German cultural history." Gunter was also a founding member of the board of directors of Research Foundation to Cure AIDS, a U.S. not-for-profit research organization.

Personal life

Blobel lost his older sister to aerial bombing of a train she was on in 1945, shortly after the bombing of Dresden, while an older brother survived the war and became a veterinarian in the United States. Blobel worked at the

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

New York City New York, often called New York City (NYC), is the most populous city in the United States, located at the southern tip of New York State on one of the world's largest natural harbors. The city comprises five boroughs, each coextensive w ...

from 1968. He lived in

Upper East Side The Upper East Side, sometimes abbreviated UES, is a neighborhood in the boroughs of New York City, borough of Manhattan in New York City. It is bounded approximately by 96th Street (Manhattan), 96th Street to the north, the East River to the e ...

with his wife, Laura Maioglio (owner of Barbetta). He was on the board of directors for

Nestlé Nestlé S.A. ( ) is a Swiss multinational food and drink processing conglomerate corporation headquartered in Vevey, Switzerland. It has been the largest publicly held food company in the world, measured by revenue and other metrics, since 20 ...

and the Board of Scientific Governors at

The Scripps Research Institute Scripps Research is a nonprofit American medical research facility that focuses on research and education in the biomedical sciences. Headquartered in San Diego, California, the institute has over 170 laboratories employing 2,100 scientists, tec ...

. Furthermore, he was Co-Founder and Chairman of the Scientific Advisory Board for Chromocell Corporation. He sat on the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize. Blobel had a passion for opera and architecture, in addition to his passion for experimental science.

Scientific awards

* 1978: NAS Award in Molecular Biology * 1982: Gairdner Foundation International Award * 1983: Otto Warburg Medal * 1983: Richard Lounsbery Award * 1983: Member of the

German Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academi ...

* Member of the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

* 1984: Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

* 1986: V. D. Mattia Award * 1986: E.B. Wilson Medal * 1986: Keith R. Porter Lecture * 1987:

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

from

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

* 1989: Waterford Bio-Medical Science Award * 1989: Member of the

American Philosophical Society The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...

* 1992: Max Delbrück Medal * 1993:

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the Lasker Award, prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Phys ...

* 1995: Ciba Drew Award in Biomedical Research * 1996: King Faisal International Prize * 1997: Mayor's Award for Excellence in Science and Technology * 1999: Massry Prize from the Keck School of Medicine,

University of Southern California The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in ...

* 1999:

* 2001:

Pontifical Academy of Sciences The Pontifical Academy of Sciences (, ) is a Academy of sciences, scientific academy of the Vatican City, established in 1936 by Pope Pius XI. Its aim is to promote the progress of the mathematical, physical, and natural sciences and the study ...

* 2001:

Pour le Mérite The (; , ), also informally known as the ''Blue Max'' () after German WWI flying ace Max Immelmann, is an order of merit established in 1740 by King Frederick II of Prussia. Separated into two classes, each with their own designs, the was ...

* 2006: Inaugural class of winner of the

Great Immigrants Award The Great Immigrants Award is an annual initiative by the Carnegie Corporation of New York to honor naturalized citizens of the United States who have made significant contributions to American society, democracy, and culture. Established in 200 ...

named by

Carnegie Corporation of New York The Carnegie Corporation of New York is a philanthropic fund established by Andrew Carnegie in 1911 to support education programs across the United States, and later the world. Since its founding, the Carnegie Corporation has endowed or othe ...

* 2008: Foreign Member of the Russian Academy of Science * 2014: AACR Academy

References

External links

Blobel's page at Rockefeller University
*
Freeview video 'An Interview with Günter Blobel' by the Vega Science Trust

Official site of the Louisa Gross Horwitz Prize

Information about Blobel as Distinguished German-American of the Year 2005
(German-American Heritage Foundation) {{DEFAULTSORT:Blobel, Gunter 1936 births 2018 deaths People from Żagań County American Nobel laureates 20th-century German biologists Members of the European Molecular Biology Organization German Nobel laureates Members of the United States National Academy of Sciences Members of the Pontifical Academy of Sciences Foreign members of the Russian Academy of Sciences Directors of Nestlé Nobel laureates in Physiology or Medicine People from the Province of Lower Silesia Recipients of the Pour le Mérite (civil class) Richard-Lounsbery Award laureates Scripps Research Goethe University Frankfurt alumni University of Freiburg alumni University of Kiel alumni Ludwig Maximilian University of Munich alumni University of Tübingen alumni University of Wisconsin–Madison alumni Howard Hughes Medical Investigators Recipients of the Albert Lasker Award for Basic Medical Research Massry Prize recipients Knights Commander of the Order of Merit of the Federal Republic of Germany Fellows of the AACR Academy 20th-century American biologists Members of the German National Academy of Sciences Leopoldina Members of the American Philosophical Society Members of the National Academy of Medicine