Gerald Weissmann

Gerald Weissmann (August 7, 1930 – July 10, 2019) was an Austrian-born American physician/scientist, editor, and essayist. He was Professor Emeritus and Research Professor of Medicine (Rheumatology) at New York University School of Medicine. He was editor-in-chief (2006–16) of ''The FASEB Journal''. At the time of his death he was its book review editor. In 1965, he was one of the discoverers of liposomes and is credited with coining that term.

Early life and education

Weissmann was born in Vienna, Austria, on August 7, 1930, to Adolf and Greta (Lustbader) Weissmann.HighBeam
/ref> His family, being Jewish, fled the Nazis and immigrated to the United States in 1938, and Gerald and his family became naturalized American citizens in 1943. After the Bronx High School of Science, he received a B.A. from Columbia University in 1950 and his M.D. from New York University in 1954. He also pursued an early career in art, exhibiting at a major New York gallery.

Career

After clinical training at Mount Sinai Hospital, New York in New York City and active service as captain in the U.S. Army Medical Corps, he took a research fellowship in the Department of Biochemistry at NYU (1958–59) under Nobel laureate Severo Ochoa. Lewis Thomas then selected him as chief medical resident at Bellevue Hospital Center (1959–60). Weissmann next worked at the Strangeways Research Laboratory, Cambridge England, studying cell biology under Dame Honor B. Fell to 1962. He returned to N.Y.U. School of Medicine, and was on its faculty for the rest of his career. In 1964 and 1969, he was a visiting investigator at the Babraham Institute in Cambridge, England; in 1973-1974 he was awarded a Guggenheim Foundation scholarship at the Centre de Physiologie et d'Immunologie Cellulaires, Hôpital Saint-Antoine at Sorbonne University, Paris, as a visiting investigator; and as visiting fellow at the William Harvey Research Institute at the Queen Mary University of London, in 1987.

Weissmann became Professor of Medicine at N.Y.U. in 1970, and served as director of the Division of Rheumatology from 1973 to 1999. Starting in 1970, he spent summers as an investigator and lecturer and served for 18 years as a trustee (later emeritus) at the Marine Biological Laboratory Woods Hole, MA. He was best known for having presented evidence that rheumatoid arthritis is an immune complex disease (provoked perhaps by genetic programs that misdirect immune responses to oral bacteria). His laboratory found that crises in systemic lupus erythematosus are provoked by intravascular complement activation. Using a tissue culture system containing a mixture of both leukocytes and endothelial cells, he pioneered studies in both leukocyte activation (via complement component 5a, immune complexes, etc.), and the role of salicylates and corticosteroids in cell signaling and adhesion (NF-κB and MAP kinases of MAPK3, MAPK1, and mitogen-activated protein kinase kinase).

He was responsible for the codiscovery of liposomes in 1965 and credited with coining that name by the Oxford Dictionary of the English Language (1965). He was a founder (with E.C. Whitehead) and a director of the Liposome Company, Inc. (purchased by Élan in 2000), from 1982 to 2000, and two drugs based on his liposome work, Abelcet and Myocet, are in clinical use. There are now over 940,000 references to liposomes on Google schola

Liposomes have been recognized as "one of the most successful drug delivery systems (DDS) given their established utility and success in the clinic in the past 40-50 years." Weissmann has been acknowledged as "Liposome's Literary Founder


Dr. Weissmann has received th
Lila Gruber Award for Cancer Research
two residencies at th
Rockefeller Foundation Study Center at Bellagio
the Alessandro Robecchi and Paul Klemperer awards for inflammation research, as well as the Distinguished Investigator and Presidential Gold Medal Awards of th
American College of Rheumatology
He is a foreign member of th
Accademia Nazionale dei Lincei
of Rome and th
Royal Society of Medicine of London
He was a master and past president of the American College of Rheumatology, a past president of the Harvey Society, a fellow of the American Academy of Arts and Sciences, The New York Academy of Medicine and The New York Academy of Sciences. With Joshua Lederberg, he was a founding member of the advisory boards of th
Pew Scholars in Biomedical Sciences
th
Ellison Medical Foundation
and was the founding chairman of the jury for the Prix Galie
Prix Galien USA

From 1975-2001, Weissmann was the founding editor of the journal
''Inflammation''
he edite
''MD Magazine''
from 1979-1984, and from 2006 to 2016 served as the editor-in-chief o
''The FASEB Journal''
At the time of his death he was the book review editor of that journal.

Essays

A member of PEN, Weissmann has published essays and reviews of cultural history in ''The New Republic'', the ''London Review of Books'', and ''The New York Times Book Review.'' His work has been collected in eleven volumes, among them ''The Woods Hole Cantata'' (1985) and ''The Fevers of Reason'' (2018). Recently, he has edited a special issue of The European Review < Volume 27 / Issue 1, February 2019> that revisits C.P. Snow's "Two Cultures and the Scientific Revolution" after 60 years. His work was praised for scientific insight by Jonas Salk, for literary style by Kurt Vonnegut, and for breadth of general culture by Adam Gopnik. His published volumes of essays include:

* ''The Woods Hole Cantata'' (1985)
* ''They All Laughed at Christopher Columbus'' (1987)
* ''The Doctor With Two Heads'' (1990)
* ''The Doctor Dilemma'' (1992)
* ''Democracy and DNA'' (1995)
* ''Darwin's Audubon'' (2002)
* ''The Year of the Genome'' (2002)
* ''Galileo's Gout: Science in an Age of Endarkenment'' (2007)
* ''Mortal and Immortal DNA'' (2009)
* ''Epigenetics in the Age of Twitter'' (2012)
* ''The Fevers of Reason'' (2018)

Personal life

He was married to Ann (Raphael) Weissmann in 1953, and had two children, Lisa Beth Weissmann, MD, of Mount Auburn Hospital Cambridge, MA and Andrew Weissmann, distinguished senior fellow at the N.Y.U. School of Law.

Death

He died on July 10, 2019.

References

{{DEFAULTSORT:Weissmann, Gerald
2019 deaths
1930 births
American rheumatologists
Academic journal editors
Jewish emigrants from Austria to the United States after the Anschluss
New York University Grossman School of Medicine faculty
Columbia College (New York) alumni
New York University Grossman School of Medicine alumni
Jewish American scientists
21st-century American Jews