Galapagos NV (formerly known as Galapagos Genomics) is a Belgian pharmaceutical research

company A company, abbreviated as co., is a Legal personality, legal entity representing an association of legal people, whether Natural person, natural, Juridical person, juridical or a mixture of both, with a specific objective. Company members ...

which was founded in 1999. Its headquarters are located in

Mechelen Mechelen (; ; historically known as ''Mechlin'' in EnglishMechelen has been known in English as ''Mechlin'', from where the adjective ''Mechlinian'' is derived. This name may still be used, especially in a traditional or historical context. T ...

and has additional locations in

Leiden Leiden ( ; ; in English language, English and Archaism, archaic Dutch language, Dutch also Leyden) is a List of cities in the Netherlands by province, city and List of municipalities of the Netherlands, municipality in the Provinces of the Nethe ...

Romainville Romainville () is a commune in the Seine-Saint-Denis department, located in the eastern suburbs of Paris, France. Location It is located from the center of Paris. History On 24 July 1867, a part of the territory of Romainville was detached ...

Basel Basel ( ; ), also known as Basle ( ), ; ; ; . is a city in northwestern Switzerland on the river Rhine (at the transition from the High Rhine, High to the Upper Rhine). Basel is Switzerland's List of cities in Switzerland, third-most-populo ...

Milan Milan ( , , ; ) is a city in northern Italy, regional capital of Lombardy, the largest city in Italy by urban area and the List of cities in Italy, second-most-populous city proper in Italy after Rome. The city proper has a population of nea ...

Madrid Madrid ( ; ) is the capital and List of largest cities in Spain, most populous municipality of Spain. It has almost 3.5 million inhabitants and a Madrid metropolitan area, metropolitan area population of approximately 7 million. It i ...

Boston Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...

and

Zagreb Zagreb ( ) is the capital (political), capital and List of cities and towns in Croatia#List of cities and towns, largest city of Croatia. It is in the Northern Croatia, north of the country, along the Sava river, at the southern slopes of the ...

. The company develops drugs against

rheumatoid arthritis Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects synovial joint, joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and h ...

Crohn's disease Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the ...

ulcerative colitis Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. It is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary sympto ...

psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...

systemic lupus erythematosus Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common ...

and

cystic fibrosis Cystic fibrosis (CF) is a genetic disorder inherited in an autosomal recessive manner that impairs the normal clearance of Sputum, mucus from the lungs, which facilitates the colonization and infection of the lungs by bacteria, notably ''Staphy ...

History

Galapagos Genomics NV was founded in 1999 as a joint venture between

Crucell Janssen Vaccines, formerly Crucell, is a biotechnology company specializing in vaccines and biopharmaceutical technologies. It was formed when Johnson & Johnson acquired the Dutch biotech company Crucell. Janssen Vaccines is part of Johnson & Jo ...

and

Tibotec Tibotec was a pharmaceutical company with a focus on research and development of the treatment of infectious diseases such as HIV/AIDS and hepatitis C. The company was founded in 1994 and then acquired by Johnson & Johnson and merged into its Jan ...

. The company later changed its name to Galapagos NV and completed its initial public offering on Euronext Amsterdam and Euronext Brussels in May 2005. The company uses a technological platform for its research, which is based on adenoviruses to introduce human gene sequences into a wide variety of human cell lines to knock-in or knock-down specific proteins. In 2019,

Gilead Sciences Gilead Sciences, Inc. () is an American biopharmaceutical company headquartered in Foster City, California, that focuses on researching and developing antiviral drugs used in the treatment of HIV/AIDS, hepatitis B, hepatitis C, influenza, and CO ...

and Galapagos entered into transformative research and development collaboration. Gilead and Galapagos have also agreed to amend certain terms around the development and commercialization of

filgotinib Filgotinib, sold under the brand name Jyseleca, is a medication used for the treatment of rheumatoid arthritis (RA). It was developed by the Belgian-Dutch biotech company Galapagos NV. The most common side effects include nausea (feeling sick ...

. In June 2022, the business announced it would acquire CellPoint for €125 million, with milestones of up to €100 million and AboundBio for $14million. Effective April 1, 2022 Paul Stoffels replaced cofounder and CEO of 20 years

Onno van de Stolpe Onno van de Stolpe (born 25 October 1959, Geldrop) is a Dutch businessman and used to be CEO of Galapagos NV, a drug discovery and development company. He retired in April 2022. Education Van de Stolpe obtained an MSc degree from the Agricult ...

Company

A German company, Galapagos Biopharma Germany GmbH, was established in 2019 and is headquartered in Munich, Germany. In December 2021, the company established an Austrian subsidiary, Galapagos Biopharma Austria GmbH, headquartered in Vienna, Austria.

Drugs

Filgotinib Filgotinib, sold under the brand name Jyseleca, is a medication used for the treatment of rheumatoid arthritis (RA). It was developed by the Belgian-Dutch biotech company Galapagos NV. The most common side effects include nausea (feeling sick ...

(GLPG0634) a selective inhibitor of JAK1 (

Janus kinase 1 Janus kinase 1 (JAK1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor f ...

) being developed for the treatment of

and potentially

. *

GLPG1205 GLPG1205 is an experimental drug which acts as a selective antagonist (or perhaps negative allosteric modulator) at the free fatty acid receptor GPR84. It has antiinflammatory and anti-fibrotic effects and reached Phase II human clinical trials f ...

: a first-in-class GPR84-inhibitor currently under research for the treatment of

inflammatory bowel disease Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. Crohn's disease affects the small intestine and large intestine ...

References

External links

* {{DEFAULTSORT:Galapagos NV Belgian brands Pharmaceutical companies of Belgium Pharmaceutical companies established in 1999 Companies listed on Euronext Brussels Companies listed on Euronext Amsterdam Companies based in Antwerp Province 1999 establishments in Belgium