G.D. Searle, LLC is a wholly owned

subsidiary A subsidiary, subsidiary company, or daughter company is a company (law), company completely or partially owned or controlled by another company, called the parent company or holding company, which has legal and financial control over the subsidia ...

Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...

. It is currently a trademark company and subsidiary of Pfizer, operating in more than 43 countries. It also operates as a distribution trademark for various

pharmaceuticals Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the ...

that were developed by G. D. Searle & Company (often referred to as Searle). Searle is most notable for having developed the first female

birth control pill The combined oral contraceptive pill (COCP), often referred to as the birth control pill or colloquially as "the pill", is a type of birth control that is designed to be taken orally by women. It is the oral form of combined hormonal contra ...

, and the artificial sweetener

NutraSweet The NutraSweet Company is an American nutrient company that produces and markets NutraSweet Neotame, their trademarked brand name for the high-intensity sweetener neotame. In 2021, NutraSweet was placed 43rd by FoodTalks' list of Top 50 Global ...

. Searle also developed the drug Lomotil, an antidiarrheal medication. One notable alumnus of Searle is

Donald Rumsfeld Donald Henry Rumsfeld (July 9, 1932 – June 29, 2021) was an American politician, businessman, and naval officer who served as United States Secretary of Defense, secretary of defense from 1975 to 1977 under President Gerald Ford, and again ...

, the Secretary of Defense for

George W. Bush George Walker Bush (born July 6, 1946) is an American politician and businessman who was the 43rd president of the United States from 2001 to 2009. A member of the Bush family and the Republican Party (United States), Republican Party, he i ...

in the 2000s. Prior to its 1985

merger Mergers and acquisitions (M&A) are business transactions in which the ownership of a company, business organization, or one of their operating units is transferred to or consolidated with another entity. They may happen through direct absorpt ...

with

Monsanto The Monsanto Company () was an American agrochemical and agricultural biotechnology corporation founded in 1901 and headquartered in Creve Coeur, Missouri. Monsanto's best-known product is Roundup, a glyphosate-based herbicide, developed ...

, Searle was a company mainly focusing on life sciences, specifically pharmaceuticals, agriculture, and animal health.

History

In , Gideon Daniel Searle founded Searle in

Omaha, Nebraska Omaha ( ) is the List of cities in Nebraska, most populous city in the U.S. state of Nebraska. It is located in the Midwestern United States along the Missouri River, about north of the mouth of the Platte River. The nation's List of United S ...

. The company incorporated in 1908 and established headquarters in

Skokie, Illinois Skokie (; formerly Niles Center) is a Village (United States), village in Cook County, Illinois, United States. According to the 2020 United States census, 2020 census, its population was 67,824. Skokie lies approximately north of Chicago's dow ...

in 1941. Daniel C. Searle served as the chief executive officer and president of G. D. Searle & Co from 1970 to 1977 and initially led efforts to gain FDA approval of the artificial sweetener aspartame. Between 1977 and 1985,

was CEO, and then president, of Searle. In 1985, he negotiated the acquisition of Searle by

Corporation. In 1993, a team of researchers at Searle Research and Development filed a patent application for

celecoxib Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psor ...

, which Searle developed and which became the first selective COX-2 inhibitor to be approved by the FDA on December 31, 1998. Control of this blockbuster drug was often mentioned as a key reason for Pfizer's acquisition of Pharmacia.

Products

The company manufactures prescription drugs and nuclear medicine imaging equipment. Searle is known for its release of Enovid, the first commercial oral contraceptive, in 1960. In 1996, the FDA removed all restrictions on the use of

aspartame Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSwe ...

, which enabled its use in heated and baked goods. G. D. Searle's patent on aspartame was extended in 1981 and ultimately expired in December 1992.

References

External links

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The Pill
{{Authority control Biotechnology companies of the United States Companies based in Skokie, Illinois History of Chicago Pharmaceutical companies of the United States Pfizer Pharmaceutical companies established in 1888 Health care companies based in New York (state) 1985 mergers and acquisitions 1888 establishments in Nebraska American corporate subsidiaries Companies formerly listed on the New York Stock Exchange