Frank DeStefano FACPM is a medical epidemiologist and researcher at the

Centers for Disease Control and Prevention The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgi ...

, where he is director of the Immunization Safety Office.

Education

Frank DeStefano graduated from Cortland (NY) High School in 1970. DeStefano graduated from

Cornell University Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach an ...

in 1974, receiving a Bachelor of Science degree, and the

University of Pittsburgh School of Medicine The University of Pittsburgh School of Medicine is a medical school of the University of Pittsburgh, located in Pittsburgh, Pennsylvania. The School of Medicine, also known as Pitt Med, is consistently ranked as a "Top Medical School" by '' ...

, from which he received a medical degree in 1978. He received his MPH at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...

School of Hygiene and Public Health in 1984.

Research

DeStefano is an author of a number of scientific studies concluding that vaccines, in particular

thimerosal Thiomersal (INN), or thimerosal (USAN, JAN), is an organomercury compound. It is a well-established antiseptic and antifungal agent. The pharmaceutical corporation Eli Lilly and Company gave thiomersal the trade name Merthiolate. It has been u ...

-containing ones, do not cause autism. In March 2013, for example, DeStefano was the lead author on a study in the

Journal of Pediatrics ''The Journal of Pediatrics'' is a monthly peer-reviewed medical journal that covers all aspects of pediatrics. It was established in 1932 and is published by Elsevier. Although it was originally affiliated with the American Academy of Pediatrics, ...

, which concluded that exposure of children to particular ingredients in vaccines, namely proteins and polysaccharides, did not increase their risk of

autism The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulti ...

. In addition, DeStefano et al. concluded that children with autism had received the same number of

antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. ...

s as children without. This study received widespread media attention. As director of the ISO, his research focuses primarily on alleged and real adverse reactions to vaccines, and how common these reactions are. As mentioned above, some of DeStefano's research pertains to the use of thiomersal in vaccines; for example, he co-authored a study in 2003 in

Pediatrics Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until th ...

which concluded that there was no consistent association between thimerosal-containing vaccines and neurodevelopmental disorders. In addition, he was the final author of a study on the alleged link between thimerosal and autism, authored by the

Vaccine Safety Datalink The Vaccine Safety Datalink Project (VSD) was established in 1990 by the United States Centers for Disease Control and Prevention (CDC) to study the adverse effects of vaccines. Four large health maintenance organizations, including Kaiser Perman ...

team, published in the

New England Journal of Medicine ''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. Hist ...

. This study concluded that "Our study does not support a causal association between early exposure to mercury from thimerosal-containing vaccines and immune globulins and deficits in neuropsychological functioning at the age of 7 to 10 years." Other topics he has published research on include

Guillain–Barré syndrome Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often ...

, as well as the potential link between

seizure An epileptic seizure, informally known as a seizure, is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain. Outward effects vary from uncontrolled shaking movements involving much of the body with los ...

s and the whole-cell

pertussis vaccine Pertussis vaccine is a vaccine that protects against whooping cough (pertussis). There are two main types: whole-cell vaccines and acellular vaccines. The whole-cell vaccine is about 78% effective while the acellular vaccine is 71–85% effectiv ...

MMR vaccine The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as ''MMR''. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, ...

. More generally, with regard to the VSD, he published a study in 2001 summarizing the ability of the project to reveal potential risks associated with vaccination, especially intussusception, through conduction of a population-based cohort study. Originally, however, DeStefano's research focused on the safety of

contraceptive Birth control, also known as contraception, anticonception, and fertility control, is the use of methods or devices to prevent unwanted pregnancy. Birth control has been used since ancient times, but effective and safe methods of birth contr ...

s, a topic he researched from 1982 to 1984 as a medical officer at the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

. Also in 1982, he joined the CDC as a senior epidemiologist in the

Agent Orange Agent Orange is a chemical herbicide and defoliant, one of the "tactical use" Rainbow Herbicides. It was used by the U.S. military as part of its herbicidal warfare program, Operation Ranch Hand, during the Vietnam War from 1961 to 1971. It ...

projects.

Career

After completing a residency in pediatrics at the

University of Rochester School of Medicine A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, th ...

, he joined the

Epidemic Intelligence Service The Epidemic Intelligence Service (EIS) is a program of the U.S. Centers for Disease Control and Prevention (CDC). The modern EIS is a two-year, hands-on post-doctoral training program in epidemiology, with a focus on field work. History Creation ...

in 1979. In 1982, he completed a CDC residency in

preventive medicine Preventive healthcare, or prophylaxis, consists of measures taken for the purposes of disease prevention.Hugh R. Leavell and E. Gurney Clark as "the science and art of preventing disease, prolonging life, and promoting physical and mental hea ...

. In 2004, DeStefano was appointed acting chief of the Immunization Safety Branch of the National Immunization Program, now known as the

National Center for Immunization and Respiratory Diseases The National Center for Immunization and Respiratory Diseases (NCIRD), formerly known as the National Immunization Program until April 2006, is charged with responsibility for the planning, coordination, and conduct of immunization activities in ...

. From 1992 to 1996, DeStefano held a post at the Marshfield Medical Research Foundation in

Marshfield, Wisconsin Marshfield is a city in northwest Wood and southwest Marathon counties in the U.S. state of Wisconsin. It is located at the intersection of U.S. Highway 10, Highway 13 and Highway 97. The largest city in Wood County, its population was 18,929 at t ...

. In 1996, he returned to the CDC.

Selected publications

* * *

References

{{DEFAULTSORT:DeStefano, Frank Living people Centers for Disease Control and Prevention people Cornell University alumni Thiomersal and vaccines Johns Hopkins Bloomberg School of Public Health alumni University of Pittsburgh School of Medicine alumni Year of birth missing (living people)