Friedrich Albin Hoffmann (13 November 1843, Ruhrort – 13 November 1924,

Leipzig Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as wel ...

) was a German internist. He studied medicine in

Würzburg Würzburg (; Main-Franconian: ) is a city in the region of Franconia in the north of the German state of Bavaria. Würzburg is the administrative seat of the ''Regierungsbezirk'' Lower Franconia. It spans the banks of the Main River. Würzburg is ...

, Tübingen and

Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...

, and after graduation (1868), he became an assistant to

Friedrich Theodor von Frerichs Friedrich Theodor von Frerichs (24 March 1819 – 14 March 1885) was a German pathologist born in Aurich. After earning his medical degree from the University of Göttingen in 1841, he returned to Aurich, where he spent several years working a ...

(1819-1885) in the First Medical Clinic at the

University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative o ...

. In 1872 he became habilitated for special

pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...

and

therapy A therapy or medical treatment (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a medical diagnosis. As a rule, each therapy has indications and contraindications. There are many different ...

( internal medicine), and from 1874 was a professor of internal medicine at the University of Dorpat. From 1886 to 1920 he served as a professor of internal medicine and director of the university polyclinic in

. He was considered an excellent diagnostician, dedicated to histological research in the field of internal medicine. His primary focus dealt with diseases of the bronchi and

mediastinum The mediastinum (from ) is the central compartment of the thoracic cavity. Surrounded by loose connective tissue, it is an undelineated region that contains a group of structures within the thorax, namely the heart and its vessels, the esophagu ...

as well as

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the c ...

and

metabolic disorder A metabolic disorder is a disorder that negatively alters the body's processing and distribution of macronutrients, such as proteins, fats, and carbohydrates. Metabolic disorders can happen when abnormal chemical reactions in the body alter the ...

s. With Paul Langerhans (1847-1888), he investigated the " intravital storage" of cinnabar injected intravenously into laboratory animals. The two scientists demonstrated that cinnabar was taken up by

white blood corpuscles White blood cells, also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multi ...

but not by

red blood corpuscles Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "holl ...

. They also noted the accumulation of cinnabar in fixed cells of the

bone marrow Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It is composed of hematopoietic ce ...

, in the

connective tissue Connective tissue is one of the four primary types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesenchyme derived from the mesoderm the middle embryonic germ layer. Connective tiss ...

of the

liver The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for ...

and in the

capillary system A capillary is a small blood vessel from 5 to 10 micrometres (μm) in diameter. Capillaries are composed of only the tunica intima, consisting of a thin wall of simple squamous endothelial cells. They are the smallest blood vessels in the body: ...

. These findings were part of the research that later spawned

Ludwig Aschoff Karl Albert Ludwig Aschoff (10 January 1866 – 24 June 1942) was a German physician and pathologist. He is considered to be one of the most influential pathologists of the early 20th century and is regarded as the most important German patholog ...

’s idea of the

reticuloendothelial system In anatomy the term "reticuloendothelial system" (abbreviated RES), often associated nowadays with the mononuclear phagocyte system (MPS), was originally launched by the beginning of the 20th century to denote a system of specialised cells that eff ...

Selected writings

* ''Ueber Contractilitätsvorgänge im vorderen Epithelium der Froschhornhaut'', Berlin 1868. (graduate thesis) * ''Experimental-Studien über Diabetes'', Berlin 1874. (with Carl Alfred Bock) - Experimental studies on

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

. * ''Betrachtungen über absolute Milchdiät'', Berlin 1884 - Reflections on an absolute

milk Milk is a white liquid food produced by the mammary glands of mammals. It is the primary source of nutrition for young mammals (including breastfed human infants) before they are able to digestion, digest solid food. Immune factors and immune ...

diet. * ''Lehrbuch der Constitutionskrankheiten'',

Stuttgart Stuttgart (; Swabian: ; ) is the capital and largest city of the German state of Baden-Württemberg. It is located on the Neckar river in a fertile valley known as the ''Stuttgarter Kessel'' (Stuttgart Cauldron) and lies an hour from the ...

1893. * ''Erkrankungen des Mediastinums'',

Vienna en, Viennese , iso_code = AT-9 , registration_plate = W , postal_code_type = Postal code , postal_code = , timezone = CET , utc_offset = +1 , timezone_DST ...

1896. Diseases of the

. * ''Die Reichsversicherungsordnung nach der Vorlesung über soziale Medizin für Juristen und Ärzte'', Leipzig 1921.University of Leipzig Geschichte
Professorenkatalog

References

{{DEFAULTSORT:Hoffmann, Friedrich Albin German internists 1924 deaths 1843 births People from Duisburg Academic staff of Leipzig University Academic staff of the University of Tartu 19th-century German physicians 20th-century German physicians