The fixed-dose procedure (FDP), proposed in 1992 by the

British Toxicology Society The British Toxicology Society has over 900 members (as of January 2020) who are based in over 40 countries. It is the National British professional association for toxicologists. The remit of the Society is to promote the advancement of the scien ...

, is a method to assess a substance's acute oral

toxicity Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacteria, bacterium, or plant, as well as the effect o ...

. In comparison to the older test developed in 1927, this procedure produces similar results while using fewer animals and causing less pain and suffering. As a result, in 1992 this test was proposed as an alternative to the LD50 test by the

Organisation for Economic Co-operation and Development The Organisation for Economic Co-operation and Development (OECD; , OCDE) is an international organization, intergovernmental organization with 38 member countries, founded in 1961 to stimulate economic progress and international trade, wor ...

under OECD Test Guideline 420. However, the U.S. Food and Drug Administration has begun to approve non-animal alternatives in response to research cruelty concerns and the lack of validity/sensitivity of animal tests as they relate to humans.

See also

References

Further reading