F-11,461 is a drug that acts as an agonist of the
5-HT1A receptor (K
i = 1.36 nM) that has been used as a
radioligand
A radioligand is a radioactive biochemical substance (in particular, a ligand that is radiolabeled) that is used for diagnosis or for research-oriented study of the receptor systems of the body.
In a neuroimaging application the radioligand is ...
in
PET
A pet, or companion animal, is an animal kept primarily for a person's company or entertainment rather than as a working animal, livestock, or a laboratory animal. Popular pets are often considered to have attractive appearances, intelligence ...
studies. It possesses modest affinity for the
5-HT7 (K
i = 9.1 nM) and
D4 (K
i = 8.5 nM) receptors, although the interaction of F-11,461 with these receptors is not detectable with PET due to their relative scarcity in the brain.
See also
*
Befiradol
Befiradol (F-13,640; NLX-112) is an experimental drug being studied for the treatment of levodopa-induced dyskinesia. It is a potent and selective 5-HT1A receptor full agonist.
Pharmacology
In recombinant cell lines expressing human 5-HT1A ...
*
8-OH-DPAT
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be disco ...
References
{{Serotonergics
Serotonin receptor agonists
PET radiotracers
Naphthalenes
Piperazines
Triazines
Methoxy compounds