Emil Von Behring
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Emil von Behring (; Emil Adolf von Behring), born Emil Adolf Behring (15 March 1854 – 31 March 1917), was a German physiologist who received the 1901
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...
, the first one awarded in that field, for his discovery of a
diphtheria Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...
antitoxin An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response to toxin exposure. Although they are most effective in neutralizing toxins, they can also ...
. He was widely known as a "saviour of children," as diphtheria used to be a major cause of child death. His work with the disease, as well as tetanus, has come to bring him most of his fame and acknowledgment. He was honored with
Prussian nobility 01 or '01 may refer to: * The year 2001, or any year ending with 01 * The month of January * 1 (number) Music * 01'' (Richard Müller album), 2001 * ''01'' (Son of Dave album), 2000 * ''01'' (Urban Zakapa album), 2011 * ''O1'' (Hiroyuki Sawano ...
in 1901, henceforth being known by the surname "von Behring."


Biography

Behring was born in Hansdorf, Kreis Rosenberg,
Province of Prussia The Province of Prussia (; ; pl, Prowincja Prusy; csb, Prowincjô Prësë) was a province of Prussia from 1829 to 1878. Prussia was established as a province of the Kingdom of Prussia in 1829 from the provinces of East Prussia and West Prussia ...
(now
Ławice Ławice (german: Hansdorf) is a village in the administrative district of Gmina Iława, within Iława County, Warmian-Masurian Voivodeship, in northern Poland. It lies approximately east of Iława and west of the regional capital Olsztyn. Nota ...
,
Iława County __NOTOC__ Iława County ( pl, powiat iławski) is a unit of territorial administration and local government (powiat) in Warmian-Masurian Voivodeship, northern Poland. In the years 1945-1958 it existed under the name Susz County ( pl, powiat suski ...
,
Poland Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populous ...
). His father was a schoolmaster; the family had 13 children. Between 1874 and 1878, he studied medicine at the Kaiser-Wilhelm-Akademie in
Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...
, an academy for military doctors, since his family could not afford the university. As a military doctor, he studied the action of
iodoform Iodoform (also known as triiodomethane and, inaccurately, as carbon triiodide) is the organoiodine compound with the chemical formula C H I3. A pale yellow, crystalline, volatile substance, it has a penetrating and distinctive odor (in older che ...
. Due to his work on Neurotomia opticociliaris (or optociliary neurotomy), Behring became a doctor from the institute and later was able to pass his exam for licensed work in his area of Marburg. In 1878, his service required him to be sent to Poland where he focused on septic diseases. His potential was becoming well known to many. This led to his commanded return to Prussia to study with Robert Koch. He was employed by the military as he received his grants and money from the Prussian army. For each semester of education, he owed 1 year of service as a military surgeon. This accumulated to 2 years, from 1881 to 1883 as he served under the Second Hussar regiment. A lesser known part of his studies was his research in
ophthalmology Ophthalmology ( ) is a surgical subspecialty within medicine that deals with the diagnosis and treatment of eye disorders. An ophthalmologist is a physician who undergoes subspecialty training in medical and surgical eye care. Following a medic ...
and how he furthered the understanding of the eye and its diseases. He wrote a paper during his time at Wicherkiewicz's hospital in Poznan from 1881 to 1883 on an eye tumor case that ended up with the patient dying from
leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
, but it did allow for much needed research on treatments for the eye and what the preferred pathways for surgery would be. He learned under some of the great ophthalmologists like Carl Ernst Schweigger and Wilhelm Uhthoff, leading to his interest in the subject and his writing his doctoral dissertation on it. In 1890 he published an article with
Kitasato Shibasaburō Baron was a Japanese physician and bacteriologist. He is remembered as the co-discoverer of the infectious agent of bubonic plague in Hong Kong during an outbreak in 1894, almost simultaneously with Alexandre Yersin. Kitasato was nominate ...
reporting that they had developed "antitoxins" against both
diphtheria Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and s ...
and
tetanus Tetanus, also known as lockjaw, is a bacterial infection caused by ''Clostridium tetani'', and is characterized by muscle spasms. In the most common type, the spasms begin in the jaw and then progress to the rest of the body. Each spasm usually ...
. They had injected diphtheria and tetanus toxins into
guinea-pig The guinea pig or domestic guinea pig (''Cavia porcellus''), also known as the cavy or domestic cavy (), is a species of rodent belonging to the genus '' Cavia'' in the family Caviidae. Breeders tend to use the word ''cavy'' to describe the an ...
s, goats and horses; when these animals developed immunity, they derived antitoxins (now known to contain
antibodies An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
) from their serum. This process would be called serum therapy by him at the time as he described it as a way to induce permanent immunity or "to stimulate the body's internal disinfection". These antitoxins could protect against and cure the diseases in non-immunized animals. In 1892 he started the first human trials of the diphtheria antitoxin, but they were unsuccessful. Successful treatment started in 1894, after the production and quantification of antitoxin had been optimized. During 1894, Behring was also awarded the Cameron Prize for Therapeutics of the University of Edinburgh. In 1895 he became Professor of
Hygienics Hygiene is a series of practices performed to preserve health. According to the World Health Organization (WHO), "Hygiene refers to conditions and practices that help to maintain health and prevent the spread of diseases." Personal hygiene refer ...
within the Faculty of Medicine at the
University of Marburg The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the wor ...
, a position he would hold for the rest of his life. He and the pharmacologist
Hans Horst Meyer Hans Horst Meyer (17 March 1853 – 6 October 1939) was a German pharmacologist. He studied medicine and did research in pharmacology. The Meyer-Overton hypothesis on the mode of action on general anaesthetics is partially named after him. H ...
had their laboratories in the same building, and Behring stimulated Meyer's interest in the mode of action of
tetanus toxin Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of ''Clostridium tetani'' in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally ...
. Behring won the first Nobel Prize in Physiology or Medicine in 1901 for the development of serum therapies against diphtheria. He was elected a Foreign Honorary Member of the
American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
in 1902. In 1904 he founded the Behringwerke in Marburg, a company to produce antitoxins and vaccines. At the International Tuberculosis Congress in 1905 he announced that he had discovered "a substance proceeding from the virus of tuberculosis." This substance, which he designated "T C," plays the important part in the immunizing action of his "bovivaccine", which prevents
bovine Bovines (subfamily Bovinae) comprise a diverse group of 10 genera of medium to large-sized ungulates, including cattle, bison, African buffalo, water buffalos, and the four-horned and spiral-horned antelopes. The evolutionary relationship betwe ...
tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in ...
. He tried unsuccessfully to obtain a protective and therapeutic agents for humans. Behring died at
Marburg Marburg ( or ) is a university town in the German federal state (''Bundesland'') of Hesse, capital of the Marburg-Biedenkopf district (''Landkreis''). The town area spreads along the valley of the river Lahn and has a population of approximate ...
,
Hessen-Nassau The Province of Hesse-Nassau () was a province of the Kingdom of Prussia from 1868 to 1918, then a province of the Free State of Prussia until 1944. Hesse-Nassau was created as a consequence of the Austro-Prussian War of 1866 by combining the ...
, on 31 March 1917. His name survived in the
Dade Behring Dade Behring was a company which manufactured testing machinery and supplies for the medical diagnostics industry, based in Deerfield, Illinois and Glasgow, Delaware (formerly a DuPont site). History Behring Diagnostics, a Frankfurt-based compa ...
organisation (now part of the
Siemens Healthineers Siemens Healthineers AG (formerly Siemens Healthcare, Siemens Medical Solutions, Siemens Medical Systems) is a German medical device company. It is the parent company for several medical technology companies and is headquartered in Erlangen, Germ ...
), in
CSL Behring CSL Behring is a biopharmaceutical company, manufacturing plasma-derived, and recombination therapeutic products. Its line of therapies includes products for the treatment of bleeding disorders such as hemophilia and von Willebrand Disease; prim ...
, a manufacturer of plasma-derived biotherapies, in
Novartis Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...
Behring and in the Emil von Behring Prize of the
University of Marburg The Philipps University of Marburg (german: Philipps-Universität Marburg) was founded in 1527 by Philip I, Landgrave of Hesse, which makes it one of Germany's oldest universities and the oldest still operating Protestant university in the wor ...
, the highest endowed medicine award in Germany. His
Nobel Prize medal Nobel often refers to: *Nobel Prize, awarded annually since 1901, from the bequest of Swedish inventor Alfred Nobel Nobel may also refer to: Companies *AkzoNobel, the result of the merger between Akzo and Nobel Industries in 1994 * Branobel, o ...
is now kept on display at the
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in
Geneva Geneva ( ; french: Genève ) frp, Genèva ; german: link=no, Genf ; it, Ginevra ; rm, Genevra is the List of cities in Switzerland, second-most populous city in Switzerland (after Zürich) and the most populous city of Romandy, the French-speaki ...
.


Controversy

Von Behring is believed to have cheated
Paul Ehrlich Paul Ehrlich (; 14 March 1854 – 20 August 1915) was a Nobel Prize-winning German physician and scientist who worked in the fields of hematology, immunology, and antimicrobial chemotherapy. Among his foremost achievements were finding a cure ...
out of recognition and financial reward in relation to collaborative research in diphtheria. The two men developed a diphtheria serum by repeatedly injecting the deadly toxin into a horse. The serum was used effectively during an epidemic in Germany. A chemical company preparing to undertake commercial production and marketing of the diphtheria serum offered a contract to both men, but von Behring maneuvered to claim all the considerable financial rewards for himself. To add insult to injury, only Behring received the first Nobel Prize in Medicine, in 1901, for his contributions. However, Ehrlich would go on to win the 1908 Nobel Prize in Medicine for his contribution to immunology.


Personal life

In December, 29th, 1896, Behring married the then twenty-year-old Else Spinola (1876-1936), who was a daughter of , the director of the Charité hospital in Berlin, and a
Jewish Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""The ...
-born mother – Elise Spinola, born Bendix – who had converted to Christianity upon her marriage.Derek S. Linton, ''Emil von Behring: Infectious Disease, Immunology, Serum Therapy'', American Philosophical Society, 2005, p. 198 They had six sons. They held their honeymoon at villa "Behring" on
Capri Capri ( , ; ; ) is an island located in the Tyrrhenian Sea off the Sorrento Peninsula, on the south side of the Gulf of Naples in the Campania region of Italy. The main town of Capri that is located on the island shares the name. It has been ...
1897, where Behring owned a vacation home. In 1909–1911, the Russian writer
Maxim Gorky Alexei Maximovich Peshkov (russian: link=no, Алексе́й Макси́мович Пешко́в;  – 18 June 1936), popularly known as Maxim Gorky (russian: Макси́м Го́рький, link=no), was a Russian writer and social ...
lived at this villa.


Publications

* ''Die Blutserumtherapie'' (1892) * ''Die Geschichte der Diphtherie'' (1893) * ''Bekämpfung der Infektionskrankheiten'' (1894) * ''Beiträge zur experimentellen Therapie'' (1906) * ''E. v. Behring's Gesammelte Abhandlungen'' (1915
Digital edition
by the
University and State Library Düsseldorf The University and State Library Düsseldorf (german: Universitäts- und Landesbibliothek Düsseldorf, abbreviated ULB Düsseldorf) is a central service institution of Heinrich Heine University. Along with Bonn and Münster, it is also one of th ...


See also

*
German inventors and discoverers ---- __NOTOC__ This is a list of German inventors and discoverers. The following list comprises people from Germany or German-speaking Europe, and also people of predominantly German heritage, in alphabetical order of the surname. For the li ...


References

* * * * Ulrike Enke: Salvatore dell'Infanzi
Behring and Capri
* Christoph Hans Gerhard : Trias deutschen Forschergeistes Emil von Behring Pflaum-Verlag / Munich Naturheilpraxis 71.Jahrgang January, 2018


Notes


External links

* including the Nobel Lecture on December 12, 1901 ''Serum Therapy in Therapeutics and Medical Science''
www.uni-marburg.de/behring-digital
* {{DEFAULTSORT:Behring, Emil Adolf von 1854 births 1917 deaths People from Iława County German immunologists German physiologists Humboldt University of Berlin alumni German military doctors German Nobel laureates Nobel laureates in Physiology or Medicine People from the Province of Prussia University of Marburg faculty Fellows of the American Academy of Arts and Sciences Physicians of the Charité Tetanus Diphtheria