Marcel Eugène Émile Gley (; 18 January 1857 – 24 October 1930) was a French

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...

and

endocrinologist Endocrinology (from ''endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events ...

born in

Épinal Épinal (; german: Spinal) is a commune in northeastern France and the prefecture of the Vosges department. Geography The commune has a land area of . It is situated on the river Moselle, south of Nancy. Épinal station has rail connection ...

Vosges The Vosges ( , ; german: Vogesen ; Franconian and gsw, Vogese) are a range of low mountains in Eastern France, near its border with Germany. Together with the Palatine Forest to the north on the German side of the border, they form a single ...

. He studied physiology with Henri-Étienne Beaunis at the medical school in Nancy, and afterwards worked as an assistant to

Étienne-Jules Marey Étienne-Jules Marey (; 5 March 1830, Beaune, Côte-d'Or – 15 May 1904, Paris) was a French scientist, physiologist and chronophotographer. His work was significant in the development of cardiology, physical instrumentation, aviation, cinema ...

(1830–1904) in

Paris Paris () is the capital and most populous city of France, with an estimated population of 2,165,423 residents in 2019 in an area of more than 105 km² (41 sq mi), making it the 30th most densely populated city in the world in 2020. S ...

. Later on, he received the title of ''professeur agrégé'', and in 1908 became a professor at the

Collège de France The Collège de France (), formerly known as the ''Collège Royal'' or as the ''Collège impérial'' founded in 1530 by François I, is a higher education and research establishment (''grand établissement'') in France. It is located in Paris ne ...

. He was a member of the ''

Académie de Médecine An academy ( Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary or tertiary higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy ...

'' and secretary general of the ''Société de Biologie''. He was a colleague to

Charles Richet Charles Robert Richet (25 August 1850 – 4 December 1935) was a French physiologist at the Collège de France known for his pioneering work in immunology. In 1913, he won the Nobel Prize in Physiology or Medicine "in recognition of his work on ...

(1850–1935), and with Richet, published the ''Journal de physiologie et de pathologie générale''. With Belgian

pharmacologist Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...

Jean-François Heymans Jean-François Heymans, also Jan Frans Heymans (25 December 1859, Gooik – 10 April 1932, Middelkerke) was a Belgian pharmacologist and physiologist. He was the father of physiologist Corneille Heymans, Corneille Jean François Heymans. He receiv ...

, he founded the journal ''Archives Internationales de Pharmacodynamie et de Thérapie'' (1895). In 1891 Gley was the first to discover the importance of the

parathyroid glands Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods. Humans usually have four parathyroid glands, located on the back of the thyroid gland in variable locations. The parathyroid gland produces and secretes pa ...

, which are four (or more) small

endocrine gland Endocrine glands are ductless glands of the endocrine system that secrete their products, hormones, directly into the blood. The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid ...

s lying close or embedded in the posterior surface of the

thyroid gland The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobe (anatomy), lobes. The lower two thirds of the lobes are connected by a thin band of Connective tissue, tissue cal ...

. These

gland In animals, a gland is a group of cells in an animal's body that synthesizes substances (such as hormones) for release into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland). Structure De ...

s had been recently discovered as an anatomical entity in 1880, however their importance was not understood at the time. Gley realized that the cause of

tetany Tetany or tetanic seizure is a medical sign consisting of the involuntary contraction of muscles, which may be caused by disorders that increase the action potential frequency of muscle cells or the nerves that innervate them. Muscle cramps cause ...

after thyroid operations was the inadvertent destruction of the parathyroid glands. He demonstrated this by removing the parathyroid glands from laboratory animals and witnessing their deaths from tetany. Because of his discovery, parathyroid glands have sometimes been referred to as "Gley's glands". In his studies of the thyroid, he discovered that there was much more

iodine Iodine is a chemical element with the symbol I and atomic number 53. The heaviest of the stable halogens, it exists as a semi-lustrous, non-metallic solid at standard conditions that melts to form a deep violet liquid at , and boils to a vi ...

in thyroid tissue than in the parathyroid, and noticed that when the thyroid is removed, a disturbance of iodine

metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cell ...

occurs.

References

Bibliography

Journal of Endochrinology
''Parathyroid Hormone: Past and Present'' * ''Parts of this article are based on a translation of an equivalent article at the

French Wikipedia The French Wikipedia (french: Wikipédia en français) is the French-language edition of Wikipedia, the free online encyclopedia. This edition was started on 23 March 2001, two months after the official creation of Wikipedia. It has article ...

''. {{DEFAULTSORT:Gley, Eugene 1857 births 1930 deaths People from Épinal French physiologists French endocrinologists Academic staff of the Collège de France