Ekene is a unisex given name. Notable people with the name include:
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Ekene Abubakar Adams (1985–2024), Nigerian politician
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Ekene Ibekwe (born 1985), American-Nigerian basketball player
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Ekene Ikenwa (born 1977), Nigerian footballer
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Ekene Obi (born 2003), Nigerian blogger and pharmacist
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Masculine given names