Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a
protein that in humans is encoded by the ''EIF1AX''
gene.
This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small
40S
The eukaryotic small ribosomal subunit (40S) is the smaller subunit of the eukaryotic 80S ribosomes, with the other major component being the large ribosomal subunit (60S). The "40S" and "60S" names originate from the convention that ribosomal pa ...
ribosomal subunit to the
5' cap
In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA. This process, known as mRNA capping, is highly regulated and vital in the creation o ...
of messenger RNAs.
Function
eIF1A is a small protein (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal
A-site, in a manner similar to the functionally related bacterial counterpart
IF1.
Clinical significance
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3. eIF1A is mutated in
thyroid cancers.
Interactions
EIF1AX has been shown to
interact with
IPO13.
See also
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Eukaryotic initiation factors Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an imp ...
References
Further reading
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External links
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{{gene-X-stub