Dihydrochalcone (DHC) is the
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon- hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. Th ...
with the formula C
6H
5C(O)(CH
2)
2C
6H
5. It is the reduced derivative of
chalcone
Chalcone is the organic compound C6H5C(O)CH=CHC6H5. It is an α,β-unsaturated ketone. A variety of important biological compounds are known collectively as chalcones or chalconoids.
Chemical properties
Chalcones have two absorption maxima at ...
(C
6H
5C(O)(CH)
2C
6H
5). It is white solid that is soluble in many organic solvents. Dihydrochalcone per se is often minor significance, but some derivatives occur in nature and have attracted attention as drugs.
Natural dihydrochalcones
left, Neohesperidin dihydrochalcone is a commercial artificial sweetener that features the dihydrochalcone substituent.
* Aspalathin, a C-linked dihydrochalcone glucoside found in rooibos, a common herbal tea
* Naringin dihydrochalcone, an artificial sweetener derived from naringin
* Neohesperidin dihydrochalcone, an artificial sweetener derived from citrus
*
Nothofagin
Nothofagin is a dihydrochalcone. It is a ''C''-linked phloretin glucoside found in rooibos (''Aspalathus linearis'')
and New Zealand red beech (''Nothofagus fusca''). It is a phenolic antioxidant
Antioxidants are compounds that inhibit o ...
, a C-linked phloretin glucoside found in rooibos
*
Phloretin
Phloretin is a dihydrochalcone, a type of natural phenol. It can be found in apple tree leaves and the Manchurian apricot.
Metabolism
In rats, ingested phlorizin is converted into phloretin by hydrolytic enzymes in the small intestine. Phlor ...
* Isosalipurpurin
Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′-trimethoxydihydrochalcone (methyl linderone) and 2′-hydroxy-3′,4′,5′,6′-tetramethoxydihydrochalcone (
dihydrokanakugiol
Dihydrokanakugiol is a dihydrochalcone
Dihydrochalcone (DHC) is the organic compound with the formula C6H5C(O)(CH2)2C6H5. It is the reduced derivative of chalcone (C6H5C(O)(CH)2C6H5). It is white solid that is soluble in many organic solvents. ...
) can be found in twigs of ''
Lindera lucida
''Lindera lucida'' is a species of flowering plant in the family Lauraceae. It is found in Malaysia.
Dihydrochalcones (3′,5′-dihydroxy-2′,4′,6′-trimethoxydihydrochalcone, methyl linderone, 5-hydroxy-6,7,8-trimethoxyflavone (alnetin) an ...
''.
[A dihydrochalcone from Lindera lucida. Yuan-Wah Leong, Leslie J. Harrison, , Graham J. Bennett, Azizol A. Kadir and Joseph D. Connolly, Phytochemistry, Volume 47, Issue 5, March 1998, Pp. 891-894, ]
References
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