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Demexiptiline (brand names Deparon, Tinoran) is a
The condensation between Dibenzosuberenone 222-33-5(1) and hydroxylamine (2) gives the oxime, 021-91-6(3). Base catalyzed attachment of the sidechain by reaction with 2-Chloro-N-Methylethanamine 2315-92-7(4) completed the synthesis of demexiptiline (5).
tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants, which is important for the management of depression. They are second-line drugs next to SSRIs. TCAs were discovered in the early 1950s and we ...
(TCA) used in France for the treatment of depression. It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.Synthesis
The synthesis is similar to that reported forNoxiptiline
Noxiptiline (brand names Agedal, Elronon, Nogedal), also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant (TCA) that was introduced in Europe in the 1970s for the treatment of depression. It has imipramine-like effects, acti ...
but also differs in a couple of respects.
The condensation between Dibenzosuberenone 222-33-5(1) and hydroxylamine (2) gives the oxime, 021-91-6(3). Base catalyzed attachment of the sidechain by reaction with 2-Chloro-N-Methylethanamine 2315-92-7(4) completed the synthesis of demexiptiline (5).
References
Further reading
* Dibenzocycloheptenes Ketoximes Tricyclic antidepressants {{nervous-system-drug-stub