Delucemine (NPS-1506) is a drug which acts as an

NMDA antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for humans and animals; the state of anesthesia they ind ...

and a

serotonin reuptake inhibitor A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the drug action, action of the serotonin transporter (SERT). This in turn lea ...

, and has neuroprotective effects. It was originally investigated for the treatment of

stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...

and in 2004 was studied as a potential

antidepressant Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathi ...

Origin

The structure of delucemine is based on argiotoxin 636, a NMDA antagonist isolated from the venom of '' Argiope aurantia''.

References

NMDA receptor antagonists 3-Fluorophenyl compounds Serotonin reuptake inhibitors Abandoned drugs {{nervous-system-drug-stub

Origin

See also

References