Collybistin is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...
identified as a regulator of the localization of
gephyrin, inducing the formation of
submembrane gephyrin aggregates that accumulate
glycine
Glycine (symbol Gly or G; ) is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid ( carbamic acid is unstable), with the chemical formula NH2‐ CH2‐ COOH. Glycine is one of the proteinog ...
and
GABA receptors. In 2000 it was identified as a gephyrin binding partner, and an important determinant of inhibitory
postsynaptic
Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous syste ...
membrane formation and
plasticity
Plasticity may refer to:
Science
* Plasticity (physics), in engineering and physics, the propensity of a solid material to undergo permanent deformation under load
* Neuroplasticity, in neuroscience, how entire brain structures, and the brain it ...
. Gephyrin and collybistin are recruited to developing postsynaptic membranes of inhibitory synapses by the trans-synaptic adhesion molecule neuroligin-2,
where they provide the scaffold for the clustering of inhibitory postsynaptic receptors to form a functioning inhibitory synapse.
References
GTP-binding protein regulators
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