Chromone (or 1,4-benzopyrone) is a derivative of
benzopyran
4H-1-Benzopyran is an organic compound with the formula . It is one of two isomers of benzopyran, the other being 2H-1-Benzopyran, 2H-1-benzopyran, which is more prevalent. It can be viewed as the fusion of a benzene ring to a heterocyclic pyra ...
with a substituted
keto group on the
pyran ring. It is an isomer of
coumarin.
Derivatives of chromone are collectively known as ''chromones''. Most, though not all, chromones are also
phenylpropanoids.
Examples
*
6,7-dimethoxy-2,3-dihydrochromone has been isolated from ''
Sarcolobus globosus''.
*
Eucryphin, a chromone rhamnoside, can be isolated from the bark of ''
Eucryphia cordifolia''.
*
Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms.
[HOWELL, J.B. & ALTOUNYAN, R.E. (1967). A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet, 2, 539–542]
Abstract
/ref> Cromoglicate is used as a mast cell stabilizer in allergic rhinitis, asthma and allergic conjunctivitis.
* Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US in 2008.
* Xanthone with a second aromatic ring.
See also
* Coumarin – a structural isomer
* Furanochromones
References
External links
* – "4-chromone"
*
Synthesis at organic-chemistry.org
{{Phenylpropanoid