Cholate—CoA Ligase
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Cholate—CoA ligase (, ''BAL'', ''bile acid CoA ligase'', ''bile acid coenzyme A ligase'', ''choloyl-CoA synthetase'', ''choloyl coenzyme A synthetase'', ''cholic thiokinase'', ''cholate thiokinase'', ''cholic acid:CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase'', ''THCA-CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate—CoA ligase'', ''3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)'', ''cholyl-CoA synthetase'', ''trihydroxycoprostanoyl-CoA synthetase'') is an
enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ...
''cholate:CoA ligase (AMP-forming)''. This enzyme catalyses the following
chemical reaction A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: (1) ATP +
cholate Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Cho ...
+ CoA \rightleftharpoons AMP +
diphosphate In chemistry, pyrophosphates are phosphorus oxyanions that contain two phosphorus atoms in a linkage. A number of pyrophosphate salts exist, such as disodium pyrophosphate () and tetrasodium pyrophosphate (), among others. Often pyrophosphate ...
+ choloyl-CoA : (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA \rightleftharpoons AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA This enzyme requires Mg2+ for activity.


References


External links

* {{DEFAULTSORT:Cholate-CoA ligase EC 6.2.1