Classifications of Charcot–Marie–Tooth disease refers to the types and subtypes of
Charcot–Marie–Tooth disease (CMT), a genetically and clinically heterogeneous group of inherited disorders of the
peripheral nervous system
The peripheral nervous system (PNS) is one of two components that make up the nervous system of bilateral animals, with the other part being the central nervous system (CNS). The PNS consists of nerves and ganglia, which lie outside the brain ...
characterized by progressive loss of
muscle tissue and touch sensation across various parts of the body. CMT is a result of genetic
mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mi ...
s in a number of
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
s.
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Clinical categories
Genetic subtypes
It has to be kept in mind that sometimes a particular patient diagnosed with CMT can exhibit a combination of any of the above gene mutations; thus, in these cases precise classification can be arbitrary.
References
{{DEFAULTSORT:Charcot-Marie-Tooth disease classifications
Peripheral nervous system disorders