Johnson & Johnson Innovative Medicine (formerly Janssen Pharmaceuticals) is a Belgian
pharmaceutical company
The pharmaceutical industry is a Medicine, medical industry that discovers, develops, produces, and markets pharmaceutical goods such as medications and medical devices. Medications are then administered to (or Self-medicate, self-administered b ...
headquartered in
Beerse, Belgium, and wholly owned by
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a c ...
. It was founded in 1953 by
Paul Janssen.
In 1961, Janssen Pharmaceuticals was purchased by
New Jersey
New Jersey is a U.S. state, state located in both the Mid-Atlantic States, Mid-Atlantic and Northeastern United States, Northeastern regions of the United States. Located at the geographic hub of the urban area, heavily urbanized Northeas ...
–based American corporation Johnson & Johnson, and became part of
Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), later renamed to Janssen Research and Development, LLC (JRD), which conducts research and development activities related to a wide range of human medical disorders, including
mental illness
A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...
,
neurological disorder
Neurological disorders represent a complex array of medical conditions that fundamentally disrupt the functioning of the nervous system. These disorders affect the brain, spinal cord, and nerve networks, presenting unique diagnosis, treatment, and ...
s,
anesthesia
Anesthesia (American English) or anaesthesia (British English) is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prev ...
and
analgesia
Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professionals ...
,
gastrointestinal disorders, fungal infection,
HIV/AIDS
The HIV, human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system. Without treatment, it can lead to a spectrum of conditions including acquired immunodeficiency syndrome (AIDS). It is a Preventive healthcare, pr ...
,
allergies
Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
and cancer. Janssen and
Ortho-McNeil Pharmaceutical
Ortho-McNeil Pharmaceutical (now operating under Janssen Pharmaceuticals) was a pharmaceutical company based in Raritan, New Jersey, that was formed from the merger of Ortho Pharmaceutical and McNeil Pharmaceutical in 1993. These pharmaceutical co ...
have been placed in the
Ortho-McNeil-Janssen group within Johnson & Johnson Company.
Subsidiaries
*
Actelion
Actelion Pharmaceuticals Ltd. is a pharmaceuticals and biotechnology company established in December 1997, headquartered in Allschwil near Basel, Switzerland. The company is part of Johnson & Johnson Innovative Medicine business segment.
Actel ...
*
Cilag AG
*
Janssen Biotech
Johnson & Johnson Innovative Medicine (formerly Janssen Pharmaceuticals) is a Belgian pharmaceutical company headquartered in Beerse, Belgium, and wholly owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen.
In 1961, Janssen Ph ...
(formerly ''Centocor'')
*
Janssen Vaccines (formerly ''Crucell'')
*
Tibotec
History

The roots of what would become Janssen Pharmaceuticals date back to 1933. In 1933,
Constant Janssen, the father of Paul Janssen, acquired the right to distribute the pharmaceutical products of
Richter, a Hungarian pharmaceutical company, for Belgium, the Netherlands and
Belgian Congo
The Belgian Congo (, ; ) was a Belgian colonial empire, Belgian colony in Central Africa from 1908 until independence in 1960 and became the Republic of the Congo (Léopoldville). The former colony adopted its present name, the Democratic Repu ...
. On 23 October 1934, he founded the ''N.V. Produkten Richter'' in
Turnhout
Turnhout () is a Belgium, Belgian Municipalities in Belgium, municipality and city located in the Flemish Region, Flemish Provinces of Belgium, province of Antwerp (province), Antwerp. The municipality comprises only the city of Turnhout proper. ...
. In 1937, Constant Janssen acquired an old factory building in the ''Statiestraat 78'' in
Turnhout
Turnhout () is a Belgium, Belgian Municipalities in Belgium, municipality and city located in the Flemish Region, Flemish Provinces of Belgium, province of Antwerp (province), Antwerp. The municipality comprises only the city of Turnhout proper. ...
for his growing company, which he expanded during
World War II
World War II or the Second World War (1 September 1939 – 2 September 1945) was a World war, global conflict between two coalitions: the Allies of World War II, Allies and the Axis powers. World War II by country, Nearly all of the wo ...
into a four-story building. Still a student, Paul Janssen assisted in the development of
paracetamol
Paracetamol, or acetaminophen, is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol.
Parac ...
(USP: acetaminophen, often referred to generically under the trademark
Tylenol) under the name
Perdolan, which would later become well-known. After the war, the name for the company products was changed to ''Eupharma'', although the company name ''Richter'' would remain until 1956.
Paul Janssen founded his own research laboratory in 1953 on the third floor of the building in the ''Statiestraat'', still within the ''Richter-Eupharma'' company of his father. In 1955, he and his team developed their first drug, Neomeritine (
ambucetamide), an antispasmodic found to be particularly effective for the relief of menstrual pain. On 5 April 1956, the name of the company was changed to ''NV Laboratoria Pharmaceutica C. Janssen'' (named after Constant Janssen). On 27 April 1957, the company opened a new research facility in Beerse, but the move to Beerse would not be completed until 1971 to 1972. On 2 May 1958, the research department in Beerse became a separate legal entity, the ''N.V. Research Laboratorium C. Janssen''.
On 25 October 1961, the company was acquired by the American corporation
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a c ...
. The negotiations with Johnson & Johnson were led by
Frans Van den Bergh, head of the board of directors. On 10 February 1964, the name was changed to ''Janssen Pharmaceutica N.V.'' and the seat of the company in Turnhout was also transferred to Beerse. The company was led by Paul Janssen,
Bob Stouthuysen and Frans Van Den Bergh. When, in 1971 to 1972 the pharmaceutical production also moved to Beerse, the move from Turnhout was completed. Between 1990 and 2004, Janssen expanded worldwide, and the company grew to about 28,000 employees worldwide.
From the beginning, Janssen emphasized research on new drug development as its core activity. The research department established in Beerse in 1957, developed into a large research campus. In 1987, the Janssen Research Foundation (JRF) was founded to perform research into new drugs at Beerse and in other laboratories around the globe. Janssen became the Flemish company with the largest budget for research and development. Beside the headquarters in Beerse with its research departments, pharmaceutical production and the administrative departments, Janssen Pharmaceutica still has offices in Belgium in
Berchem
Berchem () is a southern Districts of Antwerp, district of the municipality and city of Antwerp in the Flemish Region of Belgium. Berchem is located along the old ''Grote Steenweg'' (Dutch language, Dutch for 'Big Paved Road') that has connected ...
(
Janssen-Cilag), a chemical factory in
Geel
Geel () is a municipality and city located in the Belgian province of Antwerp, which acquired city status in the 1980s. It comprises Central-Geel which is constituted of 4 old parishes a/o towns: Sint-Amand, Sint-Dimpna, Holven and Elsum. Furthe ...
, and
Janssen Biotech
Johnson & Johnson Innovative Medicine (formerly Janssen Pharmaceuticals) is a Belgian pharmaceutical company headquartered in Beerse, Belgium, and wholly owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen.
In 1961, Janssen Ph ...
in
Olen.
The chemical production plant in Geel makes
active ingredient
An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals.
...
s for the company's medicines. In 1975, the first plant of a new chemical factory ''Plant I'' was established in Geel, ''Plant II'' was opened in 1977, ''Plant III in 1984, and ''Plant IV'' in 1995. In 1999 the remaining chemical production in Beerse was transferred to Geel. About 80% of its active components are manufactured there. The site in Geel also manufactures about two-thirds of the worldwide chemical production of the pharmaceutical sector of
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a c ...
. In 1995, the ''Center for Molecular Design'' (CMD) was founded by Paul Janssen and
Paul Lewi.
In 1999, clinical research and non-clinical development become a global organization within Johnson & Johnson. In 2001, part of the research activities was transferred to the United States with the reorganization of research activities in the ''Johnson & Johnson Pharmaceutical Research Development'' (JJPRD) organization. The research activities of the ''Janssen Research Foundation'' (JRF) and the ''R.W. Johnson Pharmaceutical Research Institute'' (PRI) (United States) were merged into the new global research organization. A new building for pharmaceutical development was completed in Beerse in 2001. In 2002, a new logistics and informatics centre was opened at a new site, ''Beerse 2''. In 2003 two new research buildings were constructed, the ''Discovery Research Center'' (DRC), and the ''Drug Safety Evaluation Center'' (DSEC). On 27 October 2004, the ''Paul Janssen Research Center'', for discovery research, was inaugurated.
In 2011, Johnson & Johnson subsidiary Centocor became
Janssen Biotech
Johnson & Johnson Innovative Medicine (formerly Janssen Pharmaceuticals) is a Belgian pharmaceutical company headquartered in Beerse, Belgium, and wholly owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen.
In 1961, Janssen Ph ...
, part of Janssen Pharmaceuticals.
Also in 2011, Johnson & Johnson acquired Crucell, and assigned it to Janssen. The acquisition of Crucell provided Janssen with a disease prevention arm. By 2014, Crucell was renamed
Janssen Vaccines.
In March 2015, Janssen licensed
tipifarnib (a
farnesyl transferase inhibitor) to Kura Oncology who will assume sole responsibility for developing and commercialising the anti-cancer drug. Later in the same month the company announced that
Galapagos Pharma had regained the rights to the anti-inflammatory drug candidate
GLPG1690 as well as two other compounds including
GLPG1205 (a first-in-class inhibitor of
GPR84).
In May 2016, the company launched a collaboration
MacroGenics and the preclinical cancer treatment, MGD015. The deal could net MacroGenics more than $740 million.
In September 2017 Janssen teamed up with the
Biomedical Advanced Research and Development Authority
The Biomedical Advanced Research and Development Authority (BARDA) is a center within the Administration for Strategic Preparedness and Response (ASPR) located within the U.S. Department of Health and Human Services (HHS) responsible for the p ...
(BARDA), a unit of the
U.S. Department of Health and Human Services, to create pandemic
flu vaccines. BARDA gave Janssen $43 million in the first year and $273 million over five years for the contract. One of the projects in the contract is the development of a universal flu vaccine. The intent of the vaccine would be to protect people against all or most flu strains.
On 5 March 2019, the
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
approved Janssen's
Spravato (
esketamine
Esketamine, sold under the brand names Spravato (for depression (mood), depression) and Ketanest (for anesthesia) among others, is the ''S''(+) enantiomer of ketamine. It is a dissociative hallucinogen drug used as a general anesthetic and as ...
nasal spray
Nasal sprays are used to deliver medications Route of administration#Local, locally in the nasal cavities or systemic administration, systemically. They are used locally for conditions such as nasal congestion and allergic rhinitis. In some sit ...
) for treatment-resistant
major depressive disorder
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive depression (mood), low mood, low self-esteem, and anhedonia, loss of interest or pleasure in normally ...
. This marked the first approval of a new type of antidepressant in decades.
In 2021, Janssen became a defendant in a trial against several opioid manufacturers filed by New York Attorney General
Letitia James
Letitia Ann "Tish" James (born October 18, 1958) is an American lawyer and politician serving since 2019 as the 67th Attorney General of New York, attorney general of New York (NYAG), having won the 2018 New York Attorney General election, 2018 ...
. The company was removed from the case after Johnson & Johnson agreed to a pay a $230 million settlement to New York State.
Janssen Biotech
The subsidiary Janssen Biotech, Inc. was founded in
Philadelphia
Philadelphia ( ), colloquially referred to as Philly, is the List of municipalities in Pennsylvania, most populous city in the U.S. state of Pennsylvania and the List of United States cities by population, sixth-most populous city in the Unit ...
in 1979 as Centocor Biotech, Inc., with an initial goal to develop new diagnostic assays using
monoclonal antibody
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
Monoclonal antibodie ...
technology.
Centocor Biotech
In 1982, Centocor became a publicly traded company.
In the early 1980s, the company moved to
Malvern, Pennsylvania
Malvern is a borough in Chester County, Pennsylvania, United States. It is west of Philadelphia. The population was 3,419 at the 2020 census.
History
The area was originally settled in the 17th century by Welsh immigrants who purchased lan ...
.
In 1984, Centocor opened an overseas plant in
Leiden
Leiden ( ; ; in English language, English and Archaism, archaic Dutch language, Dutch also Leyden) is a List of cities in the Netherlands by province, city and List of municipalities of the Netherlands, municipality in the Provinces of the Nethe ...
, the
Netherlands
, Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Nether ...
.
In 1997, eighteen years after its foundation, Centocor achieved its first year of operating profitability. In 1998, Centocor sold its diagnostic division to
Fujirebio, Inc.
In 1999, Centocor became a wholly owned subsidiary of
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational pharmaceutical, biotechnology, and medical technologies corporation headquartered in New Brunswick, New Jersey, and publicly traded on the New York Stock Exchange. Its common stock is a c ...
.
In 2004, Centocor purchased a new manufacturing plant in
St. Louis, Missouri
St. Louis ( , sometimes referred to as St. Louis City, Saint Louis or STL) is an Independent city (United States), independent city in the U.S. state of Missouri. It lies near the confluence of the Mississippi River, Mississippi and the Miss ...
, and is opening a new manufacturing facility in
County Cork, Ireland
County Cork () is the largest and the southernmost county of Ireland, named after the city of Cork, the state's second-largest city. It is in the province of Munster and the Southern Region. Its largest market towns are Mallow, Macroom, Mi ...
. The Dutch plant has been expanded substantially with a $250 million investment in additional production facilities, which were opened in 2006.
In 2007, Centocor broke new ground in advertising by releasing
Innerstate, believed to be the first theatrically released documentary film both created and entirely funded by a drug company, to promote Remicade (
Infliximab
Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing ...
).
Centocor Ortho Biotech
In 2008, Centocor, Inc. and Ortho Biotech Inc. merged to form Centocor Ortho Biotech Inc.
In June 2010, Centocor Ortho Biotech acquired RespiVert, a privately held
drug discovery
In the fields of medicine, biotechnology, and pharmacology, drug discovery is the process by which new candidate medications are discovered.
Historically, drugs were discovered by identifying the active ingredient from traditional remedies or ...
company focused on developing small-molecule, inhaled therapies for the treatment of pulmonary diseases.
As Janssen Biotech
In June 2011, Centocor Ortho Biotech changed its name to Janssen Biotech, Inc. as part of a global effort to unite the Janssen Pharmaceutical Companies around the world under a common identity.
In December 2014, the company announced it would co-develop
MacroGenics cancer drug candidate (
MGD011) which targets both
CD19
B-lymphocyte antigen CD19, also known as CD19 molecule ( Cluster of Differentiation 19), B-Lymphocyte Surface Antigen B4, T-Cell Surface Antigen Leu-12 and CVID3 is a transmembrane protein that in humans is encoded by the gene ''CD19''. In human ...
and
CD3 proteins in treating
B-cell
B cells, also known as B lymphocytes, are a type of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasm ...
malignant tumours. This could net MacroGenics up to $700 million.
In January 2015, the company announced it would use
Ionis Pharmaceuticals
Ionis Pharmaceuticals, Inc. is a biotechnology company based in Carlsbad, California, that specializes in discovering and developing RNA-targeted therapeutics. The company has three commercially approved medicines: Spinraza ( Nusinersen), Tegse ...
' (formerly Isis Pharmaceuticals) RNA-targeting technology to discover and develop
antisense
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, ...
drugs targeting autoimmune disorders of the gastrointestinal tract.
In December 2019, XBiotech Inc. announced it would sell its novel antibody treatment (
bermekimab) that neutralizes
interleukin-1
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
Discovery
Discovery of these cytokines began with studies on t ...
alpha (IL-1⍺) to Janssen Biotech, Inc.
COVID-19 vaccine development
On 27 March 2020, the U.S.
Biomedical Advanced Research and Development Authority
The Biomedical Advanced Research and Development Authority (BARDA) is a center within the Administration for Strategic Preparedness and Response (ASPR) located within the U.S. Department of Health and Human Services (HHS) responsible for the p ...
(BARDA) allocated $456 million for J&J (Janssen) to develop a vaccine against the
novel coronavirus
Novel coronavirus (nCoV) is a provisional name given to coronaviruses of medical significance before a permanent name is decided upon. Although coronaviruses are endemic in humans and infections normally mild, such as the common cold (caused by ...
.
In China

Janssen Pharmaceuticals was the first Western pharmaceutical company to set up a pharmaceutical factory in the People's Republic of China.
[Magiels, 2004]
In 1976, Paul Janssen met
Ma Haide (born George Shafik Hatem), a Lebanese-American doctor who had started working in China in 1933. After three days of meetings, the two agreed to bring a modernized pharmaceutical business to China. When
Deng Xiaoping
Deng Xiaoping also Romanization of Chinese, romanised as Teng Hsiao-p'ing; born Xiansheng (). (22 August 190419 February 1997) was a Chinese statesman, revolutionary, and political theorist who served as the paramount leader of the People's R ...
opened China to the West in 1978, Janssen sent
Paul Appermont and
Joos Horsten to set up the project.
[
In 1983, Janssen signed a cooperative contract to modernize production in an old chemical factory in the city of ]Hanzhong
Hanzhong ( zh, s= , t= , l=middle of the Han River (Hubei), Han River; abbreviation: Han) is a prefecture-level city in Southern Shaanxi, the southwest of Shaanxi, Shaanxi province, China, bordering the provinces of Sichuan to the south and Gans ...
, in Shaanxi
Shaanxi is a Provinces of China, province in north Northwestern China. It borders the province-level divisions of Inner Mongolia to the north; Shanxi and Henan to the east; Hubei, Chongqing, and Sichuan to the south; and Gansu and Ningxia to t ...
. This factory would soon produce the active compound of Janssen products such as mebendazole
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid di ...
. In 1985, operating as Xian-Janssen Pharmaceuticals, a large factory was opened in the city of Xi'an
Xi'an is the list of capitals in China, capital of the Chinese province of Shaanxi. A sub-provincial city on the Guanzhong plain, the city is the third-most populous city in Western China after Chongqing and Chengdu, as well as the most populou ...
, also in Shaanxi province.[
]
Drugs developed
Janssen Pharmaceuticals has developed and brought to the market about 70 new active substances ( NCE), of which the most well-known are (name may differ):
* Imodium (against diarrhoea. Active substance: loperamide
Loperamide, sold under the brand name Imodium, among others,Drugs.co Page accessed 4 September 2015 is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. It is often used for this purpose in irritable ...
)
* Motilium (against flatulence and bowel impairments. Active substance: domperidone
Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). It raises the ...
)
* Reminyl (against Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...
(dementia). Active substance: galantamine
Galantamine is a type of acetylcholinesterase inhibitor. It is an alkaloid extracted from the bulbs and flowers of ''Galanthus nivalis'' (common snowdrop), '' Galanthus caucasicus'' (Caucasian snowdrop), '' Galanthus woronowii'' (Voronov's snow ...
)
* Daktarin (against fungal infections. Active substance: miconazole
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. It is used for ring worm of the body, groin (jock itch), a ...
)
* Nizoral (against dandruff
Dandruff is a skin condition of the scalp. Symptoms include flaking and sometimes mild itchiness. It can result in social or self-esteem problems. A more severe form of the condition, which includes inflammation of the skin, is known as s ...
, Active substance: ketoconazole
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal drug, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin inf ...
)
* Duragesic (fentanyl patch for pain suppression. Active substance: fentanyl
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic (pain medication). It is 30 to 50 times more Potency (pharmacology), potent than heroin and 50 to 100 times more potent than morphine. Its primary Medici ...
)
* Vermox (against intestinal worms. Active substance: mebendazole
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid di ...
)
* Risperdal
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is ta ...
(antipsychotic, against mental illness such as schizophrenia. Active substance: risperidone
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is t ...
)
WHO Model List of Essential Medicines
Eight original Janssen drugs have been included on the WHO Model List of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...
:
* Imodium (loperamide
Loperamide, sold under the brand name Imodium, among others,Drugs.co Page accessed 4 September 2015 is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. It is often used for this purpose in irritable ...
)
* Haldol (haloperidol
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychos ...
)
* Ergamisol (levamisole
Levamisole, sold under the brand name Ergamisol among others, is a medication used to treat parasitic worm infections, specifically ascariasis and hookworm infections. It is taken by mouth.
Side effects may include abdominal pain, vomiting, ...
)
* Daktarin (miconazole
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. It is used for ring worm of the body, groin (jock itch), a ...
)
* Vermox (mebendazole
Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. This includes ascariasis, pinworm infection, hookworm infections, guinea worm infections and hydatid di ...
)
* Nizoral (ketoconazole
Ketoconazole, sold under the brand name Nizoral, among others, is an antiandrogen, antifungal drug, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections. Applied to the skin it is used for fungal skin inf ...
) (Removed in 2005)
* Risperdal (risperidone
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is t ...
)
* Sirturo ( bedaquiline) – an diarylquinoline anti-tuberculosis drug, discovered by Koen Andries and his team, which promises a shorter and simpler treatment for multi-drug-resistant tuberculosis
Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are Antimicrobial resistance, resistant to treatment with at least two of the most powerful first-line Tuberculosis management, anti-TB m ...
(MDR-TB).
Centocor products
In 1984, Centocor developed their first product approved by the U.S. Food and Drug Administration (FDA) – a diagnostic test used to detect the rabies
Rabies is a viral disease that causes encephalitis in humans and other mammals. It was historically referred to as hydrophobia ("fear of water") because its victims panic when offered liquids to drink. Early symptoms can include fever and abn ...
virus.
In 1998, the company launched its top-selling monoclonal antibody Remicade (infliximab
Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing ...
) for its first FDA approved indication in Crohn's disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea, fever, abdominal distension, and weight loss. Complications outside of the ...
. Subsequently, Remicade's market has expanded with approvals for rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects synovial joint, joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and h ...
, ankylosing spondylitis
Ankylosing spondylitis (AS) is a type of arthritis from the disease spectrum of axial spondyloarthritis. It is characterized by long-term inflammation of the joints of the spine, typically where the spine joins the pelvis. With AS, eye and bow ...
, psoriatic arthritis
Psoriatic arthritis (PsA) is a long-term inflammatory arthritis that may occur in some people affected by the autoimmune disease psoriasis. The classic features of psoriatic arthritis include dactylitis (sausage-like swelling of the fingers ...
, ulcerative colitis
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. It is a long-term condition that results in inflammation and ulcers of the colon and rectum. The primary sympto ...
, and pediatric
Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, pediatrics covers many of their youth ...
Crohn's disease. Remicade was approved for plaque psoriasis in September 2006.
Centocor also markets ReoPro ( abciximab), a biologic agent indicated as an adjunct to coronary angioplasty
Angioplasty, also known as balloon angioplasty and percutaneous transluminal angioplasty, is a minimally invasive procedure, minimally invasive endovascular surgery, endovascular Medical procedure, procedure used to widen narrowed or obstructe ...
( PTCA).
In 2009, the U.S. FDA approved Simponi, a human monoclonal antibody for treatment for arthritis, which was co-developed with Medarex, Inc.
Risperdal deception
In 2004, the United States Department of Justice
The United States Department of Justice (DOJ), also known as the Justice Department, is a United States federal executive departments, federal executive department of the U.S. government that oversees the domestic enforcement of Law of the Unite ...
began investigating sales practices surrounding the antipsychotic drug risperidone
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is t ...
(Risperdal
Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is ta ...
). In 2010, the agency joined a whistleblower
Whistleblowing (also whistle-blowing or whistle blowing) is the activity of a person, often an employee, revealing information about activity within a private or public organization that is deemed illegal, immoral, illicit, unsafe, unethical or ...
suit alleging that despite being warned by the U.S. Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
not to promote Risperdal as effective and safe for elderly patients, in whom it was known to be associated with early death, Johnson & Johnson and Janssen Pharmaceuticals paid pharmacists at Omnicare, the largest supplier of pharmaceuticals to nursing homes, tens of millions of dollars in bribes and kickbacks to promote the drug to physicians for this unapproved use.
The lawsuit resulted in a 2012 provisional settlement totaling $2.3 billion,[J&J Said to Agree to $2.2 Billion Drug Marketing Accord]
Bloomberg News. By Margaret Cronin Fisk, Jef Feeley & David Voreacos – 11 June 2012 with Omnicare having already settled for around $100 million.[ Four states were awarded damages: Louisiana ($258 million in 2010), South Carolina ($327 million in 2011), Texas ($158 million in 2012), and Arkansas ($1.2 billion in 2012).
Former head of sales and president of Janssen ]Alex Gorsky
Alex Gorsky (born 1960) is an American businessman. He is the former chairman and CEO of Johnson & Johnson. Gorsky stepped down as CEO of Johnson & Johnson in January 2022 and was succeeded by Joaquin Duato. He was the seventh person who was the ...
, who according to the Department of Justice "was actively involved" in the fraud, became CEO of Johnson & Johnson in 2012.J&J needs a cure: new CEO allegedly had links to fraud
Forbes, Erika Kelton, 17 April 2012
See also
* Janssen-Cilag
* Didier de Chaffoy de Courcelles
* Paul Stoffels
* Staf Van Reet
* Jan Schuurkes
* Tibotec
* Rega Institute for Medical Research
* Drug development
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regu ...
* Nanovid microscopy
* Joan Daemen
Joan Daemen (; born 1965) is a Belgians, Belgian cryptographer who is currently professor of digital security (symmetric encryption) at Radboud University. He co-designed with Vincent Rijmen the Rijndael cipher, which was selected as the Advance ...
*
* List of companies of Belgium
* List of pharmaceutical companies
This listing is limited to those pharmaceutical companies, independent companies and subsidiaries notable enough to have their own articles in Wikipedia. Both going concerns and defunct firms are included, as well as firms that were part of the ...
References
Bibliography
* Magiels, Geerdt (2004). ''Paul Janssen – Pionier in farma en in China'' (in Dutch). Antwerp
Antwerp (; ; ) is a City status in Belgium, city and a Municipalities of Belgium, municipality in the Flemish Region of Belgium. It is the capital and largest city of Antwerp Province, and the third-largest city in Belgium by area at , after ...
, Amsterdam: Houtekiet. .
External links
Janssen Pharmaceutica
{{Authority control
Johnson & Johnson subsidiaries
Pharmaceutical companies of Belgium
Companies based in Antwerp Province
Beerse
Pharmaceutical companies established in 1953
Biotechnology companies established in 1953
1961 mergers and acquisitions
Belgian brands
Belgian companies established in 1953
COVID-19 vaccine producers
Medical research
Belgian subsidiaries of foreign companies