Cell Signaling Technology, Inc. (CST) is a

privately held company A privately held company (or simply a private company) is a company whose Stock, shares and related rights or obligations are not offered for public subscription or publicly negotiated in their respective listed markets. Instead, the Private equi ...

that develops and produces

antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ...

ELISA The enzyme-linked immunosorbent assay (ELISA) (, ) is a commonly used analytical biochemistry assay, first described by Eva Engvall and Peter Perlmann in 1971. The assay is a solid-phase type of enzyme immunoassay (EIA) to detect the presence of ...

kits, ChIP kits, proteomic kits, and other related reagents used to study the

cell signaling In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biol ...

pathways that impact human health. CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

History

Cell Signaling Technology was founded in 1999 by scientists in the Cell Signaling group at

New England Biolabs New England Biolabs (NEB) is an American life sciences company which produces and supplies recombinant and native enzyme reagents for life science research. It also provides products and services supporting genome editing, synthetic biology and ...

(NEB).A lab with a view: New research space reflects company's open, research-driven philosophy
/ref> Originally housed in the Cummings Center (

Beverly, Massachusetts Beverly is a city in Essex County, Massachusetts, United States, and a suburb of Boston. The population was 42,670 at the time of the 2020 United States census. A resort, residential, and manufacturing community on the Massachusetts North Sho ...

), CST moved to its current United States headquarters located at the former King’s Grant Inn (

Danvers, Massachusetts Danvers is a New England town, town in Essex County, Massachusetts, United States, located on the Danvers River near the northeastern coast of Massachusetts. The suburb is a fairly short ride from Boston and is also in close proximity to the beach ...

) in late 2005. Following extensive renovation, the U.S. Green Building Council has certified the current headquarters as a LEED (Leadership in Energy and Environmental Design) certified facility in 2007. In 2008 and 2009, CST expanded its overseas operations, establishing subsidiary offices in the

People’s Republic of China China, officially the People's Republic of China (PRC), is a country in East Asia. With a population exceeding 1.4 billion, it is the second-most populous country after India, representing 17.4% of the world population. China spans the e ...

Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...

, and the

Netherlands , Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Nether ...

.Cell Signaling Technology buys Dutch distributor
/ref> In 2013, CST moved its production group into an ISO9001 certified facility in Beverly, Massachusetts. Cell Signaling Technology was named as one of the “Top 100 Places to Work” in a 2009-2013 survey published by the Boston Globe.Globe Top 100 Places to Work
/ref>

Research

In addition to product development and production, CST is also involved in the development of new technologies for signaling analysis as well as mechanistic cell biology research, particularly in the field of cancer research. CST curates and maintains PhosphoSitePlus, a web-based bioinformatics resource that details

post-translational modifications In molecular biology, post-translational modification (PTM) is the covalent process of changing proteins following protein biosynthesis. PTMs may involve enzymes or occur spontaneously. Proteins are created by ribosomes, which translation (biolog ...

(PTMs) in human, mouse and rat proteins. The types of PTMs curated include phosphorylation, acetylation, methylation, ubiquitylation, glycosylation, etc. This freely accessible, online resource is funded in part through grant support from the NIH, and most recently through the NIH BD2K initiative.

Notable employees

* Klarisa Rikova

References

External links

Cell Signaling Technology, Inc. web site

PhosphoSitePlus web site
{{Authority control Biotechnology companies established in 1999 Companies based in Beverly, Massachusetts Biotechnology companies of the United States Life science companies based in Massachusetts Research support companies 1999 establishments in Massachusetts Companies based in Danvers, Massachusetts Privately held companies of the United States American companies established in 1999