Cartwheel cells are neurons of the dorsal cochlear nucleus (DCN) where they greatly outnumber the other inhibitory

interneuron Interneurons (also called internuncial neurons, relay neurons, association neurons, connector neurons, intermediate neurons or local circuit neurons) are neurons that connect two brain regions, i.e. not direct motor neurons or sensory neurons. I ...

s of the DCN. Their somas lie on the superficial side of the pyramidal layer of the DCN, and their dendrites receive input from the parallel fibres of the granule cell layer. Their axons do not extend beyond the dorsal cochlear nucleus but

synapse In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell. Synapses are essential to the transmission of nervous impulses from ...

with other cartwheel cells and pyramidal cells within the DCN releasing GABA and glycine onto their targets. Cartwheel cells have similar spiking patterns to Purkinje cells, firing complex spike bursts as well as simple spikes. They are also seen to share other features common to the cerebellar Purkinje cells. Other data supports the structural and functional similarity found between the cartwheel and the Purkinje neuron. Cartwheel cells are shown to have a high density of spines on their dendrites, their axons are myelinated, they are of spherical cell shape and of medium size. The primary targets of the cartwheel cells are the large efferent pyramidal neurons of the DCN, found in layer two. Data retrieved has shown that this targeting of the pyramidal cells modulates their activity and therefore plays a key role in the shaping of the overall output of the superficial layers of the dorsal cochlear nucleus.

References

{{DEFAULTSORT:Cartwheel cell Neurons Central nervous system neurons