Carlos Martínez Alonso
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Carlos Martínez Alonso, (Carlos Martinez-A.) was born in Villasimpliz ( Pola de Gordón), in the
province of León León (, ; ; ; ) is a province of northwestern Spain in the northern part of the Region of León and in the northwestern part of the autonomous community of Castile and León. About one quarter of its population of 463,746 (2018) lives in the c ...
, on January 9, 1950. In 1974 he obtained a
chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...
degree from the
Universidad Complutense The Complutense University of Madrid (, UCM; ) is a public research university located in Madrid. Founded in Alcalá in 1293 (before relocating to Madrid in 1836), it is one of the oldest operating universities in the world, and one of Spain's ...
of
Madrid Madrid ( ; ) is the capital and List of largest cities in Spain, most populous municipality of Spain. It has almost 3.5 million inhabitants and a Madrid metropolitan area, metropolitan area population of approximately 7 million. It i ...
. Four years later, in 1978, he obtained a Ph.D. in
immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...
by the same university. He was appointed President of the Spanish National Research Council (CSIC) from 2004 to 2008, and Secretary of State for Research in the Ministry of Science and Innovation from early 2008 to December 2009. He did his scientific research in several institutions: La Clínica Puerta de Hierro (
Autonomous University of Madrid The Autonomous University of Madrid (; UAM), commonly known as la Autónoma, is a Spanish public university located in Madrid, Spain. The university was founded in 1968 by royal decree. UAM is widely respected as one of the most prestigious univ ...
), the
Basel Institute for Immunology The Basel Institute for Immunology (BII) was founded in 1969 as a basic research institute in immunology located at 487 Grenzacherstrasse, Basel, Switzerland on the Rhine River down the street from the main Hoffmann-La Roche campus near the Swiss-G ...
(Basel, Switzerland), the Umeå University School of Medicine (Umeå, Sweden), the
Pasteur Institute The Pasteur Institute (, ) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. Th ...
(Paris, France), the
California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...
(Pasadena, California, USA), the Severo Ochoa Center for Molecular Biology (Madrid, Spain), with stays in institutions, including the Institute of Immunobiology of the Max Planck Society (Freiburg, Germany), the Ontario Cancer Institute (Toronto, Canada),
Millennium Pharmaceuticals Takeda Oncology (originally Millennium Pharmaceuticals) is a biopharmaceutical company based in Cambridge, Massachusetts. It is a fully owned subsidiary of Takeda Pharmaceutical. Takeda Oncology's research, development and commercialization ac ...
(Boston, Massachusetts, USA). He now works at the National Center for Biotechnology (CNB-CSIC) in Madrid, where he was vice-director and founded and directed the Department of Immunology and Oncology from 1996 to 2004, thanks to a large collaborative core grant from Pharmacia/
Pfizer Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 184 ...
. He is a member of the
European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
(EMBO) and was the president of the European Molecular Biology Conference from 1995 to 1999, and vice-president of the
European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 29 member states, two prospect member states, and one associate member state. EMBL was created in ...
(EMBL) in
Heidelberg Heidelberg (; ; ) is the List of cities in Baden-Württemberg by population, fifth-largest city in the States of Germany, German state of Baden-Württemberg, and with a population of about 163,000, of which roughly a quarter consists of studen ...
. He is member of the editorial committee of various international journals, and author to more than 400 articles in such scientific journals. In 2004 he was elected president of the Spanish
Spanish National Research Council The Spanish National Research Council (, CSIC) is the largest public institution dedicated to research in Spain and the third largest in Europe. Its main objective is to develop and promote research that will help bring about scientific and techn ...
(CSIC). In April 2008 he moved from this position to his present one in the Ministry for Science and Innovation, and was substituted by Rafael Rodrigo Montero at the CSIC presidency.


Scientific career and awards

As an immunologist, he has contributed significantly to the understanding of lymphocyte activation and its implication in autoimmune diseases. He identified some of the mechanisms involved in
cytokine Cytokines () are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are produced by a broad range of cells, including immune cells like macrophages, B cell, B lymphocytes, T cell, T lymphocytes ...
- and
chemokine Chemokines (), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells. In addit ...
-activated signaling pathways and their relevance in HIV-1 infection, cell migration and cancer. Today he is interested in stem cell biology, specifically in the molecular mechanisms that control self-renewal vs. differentiation of these cells, and their implication for cancer, regenerative medicine and inflammation. He has published more than 460 peer-reviewed publications in top journals. Under his leadership, a large number of PhD students and postdoctoral scientists have been trained, many of whom are presently in leading academic and biopharmaceutical institutes worldwide. He is a member of the
European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
(EMBO), the
Academia Europaea The Academia Europaea is a pan-European Academy of humanities, letters, law, and sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europe ...
, the Hassan II Academy of Sciences and Technologies or Morocco (6), and Doctor ''honoris causa'' of several universities. He is a member of Scientific Committees at
NATO The North Atlantic Treaty Organization (NATO ; , OTAN), also called the North Atlantic Alliance, is an intergovernmental organization, intergovernmental Transnationalism, transnational military alliance of 32 Member states of NATO, member s ...
, Human Frontier Scientific Program (HFSP), the EU and of the editorial board and editor for several scientific publications. He contributes regularly to science dissemination in the media, with more than 70 publications and radio and TV appearances. He has received awards from the
Spanish Royal Academy of Sciences The Spanish Royal Academy of Sciences (Spanish: ''Real Academia de Ciencias Exactas, Físicas y Naturales'') is an academic institution and learned society that was founded in Madrid in 1847. It is dedicated to the study and research of mathematic ...
, the Fundación Ciencias de la Salud, as well as the DuPont Prize for Science, the Carmen y Severo Ochoa, the Rey Jaime I Award for Scientific Research, the Lilly Award of Investigación Preclínica, the Government of Castilla and León Prize, the International Galen Award for Scientific Research, the Spanish National Award of Medicine "Gregorio Marañon", and the International Award for Science and Technology of the Government of Mexico. He holds the Gran Cruz de la Orden del Mérito Civil.


Management and entrepreneurial skills

He was a representative of Europe in the
NATO The North Atlantic Treaty Organization (NATO ; , OTAN), also called the North Atlantic Alliance, is an intergovernmental organization, intergovernmental Transnationalism, transnational military alliance of 32 Member states of NATO, member s ...
Scientific Program, member of the EMBO Scientific Council, President of the EMBC (European Molecular Biology Conference), Vice-president of the EMBL Board of Trustees (
European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 29 member states, two prospect member states, and one associate member state. EMBL was created in ...
), Vice-president of EUROHORCS (European Heads of Research Organizations) and member of the ESF Executive Board (
European Science Foundation The European Science Foundation (ESF) is an association of 11 member organizations devoted to scientific research in 8 European countries. ESF is an independent, non-governmental, non-profit organization that promotes science in Europe. It was e ...
). He was Chair for the ERC Starting Grants in 2007 and of the Life Science panel for the ERC Synergy Grants in 2012 and 2013. He was a member of the board of CDTI (Centro para el Desarrollo Tecnológico Industrial), of the executive board of the
Spanish National Library Spanish might refer to: * Items from or related to Spain: **Spaniards are a nation and ethnic group indigenous to Spain **Spanish language, spoken in Spain and many countries in the Americas **Spanish cuisine ** Spanish history **Spanish culture ...
, President of INIA (Spanish Institute for Agrobiology), of the Instituto de Salud Carlos III (Spanish Institute for Health Research), IAC (Institute of Astrophysics in the Canary Islands), IEO (Spanish Institute of Oceanography), and CIEMAT (Center for Energy, Environmental and Technological Research). With Antonio Bernad and Cristina Garmendia, he founded the biotechnology company Genetrix, and with Alfonso Valencia, Roderic Guigo and Jose Dopazo, the bioinformatics company Alma.


References

{{DEFAULTSORT:Martinez Alonso, Carlos 1950 births Living people People from Montaña Occidental Spanish biochemists Secretaries of State of Spain