Calsyntenin
Calsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes ...
-1 is a
protein that in humans is encoded by the ''CLSTN1''
gene.
Clinical relevance
Mutations in this gene have been shown associated to pathogenic mechanisms of
Alzheimer's disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term me ...
.
Interactions
CLSTN1 has been shown to
interact with
APBA2 and
Amyloid precursor protein.
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References
External links
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Further reading
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