Calmodulin-like protein 5 is a
protein that in humans is encoded by the ''CALML5''
gene.
This gene encodes a novel
calcium binding protein expressed in the
epidermis
The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. The epidermis layer provides a barrier to infection from environmental pathogens and regulates the amount of water rele ...
and related to the
calmodulin
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the bind ...
family of
calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating
keratinocytes. In addition, it can associate with
transglutaminase 3, shown to be a key enzyme in the terminal differentiation of
keratinocytes.
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EF-hand-containing proteins
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