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The Blalock–Thomas–Taussig shunt (BTT shunt), previously known as the Blalock–Taussig Shunt (BT shunt), is a surgical procedure used to increase blood flow to the lungs in some forms of
congenital heart disease A congenital heart defect (CHD), also known as a congenital heart anomaly, congenital cardiovascular malformation, and congenital heart disease, is a defect in the structure of the heart or great vessels that is present at birth. A congenital he ...
such as
pulmonary atresia Pulmonary atresia is a congenital malformation of the pulmonary valve in which the valve orifice fails to develop. The valve is completely closed thereby obstructing the outflow of blood from the heart to the lungs. The pulmonary valve is located o ...
and
tetralogy of Fallot Tetralogy of Fallot (TOF), formerly known as Steno-Fallot tetralogy, is a congenital heart defect characterized by four specific cardiac defects. Classically, the four defects are: * Pulmonary stenosis, which is narrowing of the exit from the r ...
, which are common causes of
blue baby syndrome Blue baby syndrome can refer to conditions that cause cyanosis, or blueness of the skin, in babies as a result of low blood oxygen levels. This term traditionally refers to cyanosis as a result of:. # Cyanotic heart disease, which is a categor ...
. The procedure involves connecting a branch of the
subclavian artery In human anatomy, the subclavian arteries are paired major arteries of the upper thorax, below the clavicle. They receive blood from the aortic arch. The left subclavian artery supplies blood to the left arm and the right subclavian artery suppli ...
or
carotid artery Carotid artery may refer to: * Common carotid artery, often "carotids" or "carotid", an artery on each side of the neck which divides into the external carotid artery and internal carotid artery * External carotid artery, an artery on each side of ...
to the
pulmonary artery A pulmonary artery is an artery in the pulmonary circulation that carries deoxygenated blood from the right side of the heart to the lungs. The largest pulmonary artery is the ''main pulmonary artery'' or ''pulmonary trunk'' from the heart, and ...
. In modern practice, this procedure is temporarily used to direct blood flow to the lungs and relieve cyanosis while the infant is waiting for corrective or definitive surgery when their heart is larger. The BTT shunt is used in the first step of the three-stage palliation (the Norwood procedure). __TOC__


Alternatives

While the originally described Blalock–Thomas–Taussig shunt directly connected the subclavian and pulmonary arteries, in contemporary practice a modified version of the procedure, the mBTT shunt, is more commonly used. In the modified Blalock–Thomas–Taussig shunt, a length of artificial tubing typically made from
PTFE Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer of tetrafluoroethylene, and has numerous applications because it is chemically inert. The commonly known brand name of PTFE-based composition is Teflon by Chemours, a spin-off fro ...
(
Teflon Polytetrafluoroethylene (PTFE) is a synthetic fluoropolymer of tetrafluoroethylene, and has numerous applications because it is chemically inert. The commonly known brand name of PTFE-based composition is Teflon by Chemours, a spin-off from ...
) is sewn between either the subclavian or the carotid artery and the corresponding side branch of the pulmonary artery. This modification removes the need to cut off blood supply and makes it easier to regulate the blood flow to the lungs. Some centers now use a shunt directly from the right ventricle to the pulmonary artery, a Sano shunt. This is done to avoid the reduced diastolic blood flow in the
coronary circulation Coronary circulation is the Circulatory system#Coronary vessels, circulation of blood in the arteries and veins that supply the cardiac muscle, heart muscle (myocardium). Coronary arteries supply oxygen saturation (medicine), oxygenated blood to ...
associated with the mBTT shunt.


History

The original procedure was named for
Alfred Blalock Alfred Blalock (April 5, 1899 – September 15, 1964) was an American surgeon most noted for his work on the medical condition of shock as well as tetralogy of Fallot – commonly known as blue baby syndrome. He created, with assistance from ...
, surgeon, Culloden, GA (1899–1964),
Helen B. Taussig Helen Brooke Taussig (May 24, 1898 – May 20, 1986) was an American cardiologist, working in Baltimore and Boston, who founded the field of pediatric cardiology. She is credited with developing the concept for a procedure that would extend the l ...
, cardiologist, Baltimore/Boston (1898–1986) and Vivien Thomas (1910–1985) who was at that time Blalock's laboratory assistant. They all helped to develop the procedure. Taussig, who treated hundreds of infants and children with this disorder, had observed that children with a cyanotic heart defect and a
patent ductus arteriosus Patent ductus arteriosus (PDA) is a medical condition in which the ''ductus arteriosus'' fails to close after childbirth, birth: this allows a portion of oxygenated blood from the left heart to flow back to the lungs from the aorta, which has a h ...
(PDA) lived longer than those without the PDA. It, therefore, seemed to her that a shunt that mimicked the function of a PDA might relieve the tetralogy patients' poor oxygenation. In 1943, having broached the possibility of a surgical solution to Robert Gross of Boston without success, Taussig approached Blalock and Thomas in their Hopkins laboratory in 1943. According to the account of the original consultation between the three provided in Vivien Thomas' 1985 autobiography ''Partners of the Heart'', Taussig carefully described the anomaly of Tetralogy of Fallot, but made no suggestion about the specific surgical correction required, observing merely that it should be possible to get more blood to the lungs, "as a plumber changes pipes around." Although Taussig was not aware of it at that time, Blalock and Thomas had already experimented with such an
anastomosis An anastomosis (, : anastomoses) is a connection or opening between two things (especially cavities or passages) that are normally diverging or branching, such as between blood vessels, leaf veins, or streams. Such a connection may be normal (su ...
, one that Blalock had conceived years earlier for a different purpose but which had the unanticipated effect of re-routing blood to the lungs. The operation involved the joining of the subclavian artery to the pulmonary artery. After meeting with Taussig, the two men set about perfecting the operation in the animal lab, with Thomas performing the subclavian-to-pulmonary anastomosis alone in some 200 laboratory dogs, then adapting the instruments for the first human surgery from those used on the experimental animals and coaching Blalock through the first 100 operations on infants. Thomas' autobiographical account, corroborated by the participants in the early tetralogy operations (
Denton Cooley Denton Arthur Cooley (August 22, 1920 – November 18, 2016) was an American cardiothoracic surgeon famous for performing the first implantation of a total artificial heart. Cooley was also the founder and surgeon in-chief of The Texas Hear ...
and the late William P. Longmire, Jr., intern and resident respectively during the surgery) has led to the recent conclusion that Thomas' contribution, both experimentally and clinically, was so critical that he should have received credit for the procedure along with Blalock and Taussig. However, because of the racial prejudices of the time, and the academic custom which generally precluded mention of non-degreed lab assistants (Thomas had no formal education beyond high school), he did not receive the honor of having the shunt named after him. The 2004 HBO television movie '' Something the Lord Made'', based on '' Washingtonian'' writer Katie McCabe's 1989 article of the same name, was made about his role in the historic Blue Baby surgery, as was the 2003 public television documentary ''Partners of the Heart.'' File:Blalock Taussig Shunt - Subclavian to Pulmonary.png, Blalock–Thomas–Taussig Shunt – left subclavian artery to left pulmonary artery.


References

:* ''Partners of the Heart: Vivien Thomas and His Work with Alfred Blalock'', by Vivien T. Thomas (originally published as ''Pioneering Research in Surgical Shock and Cardiovascular Surgery: Vivien Thomas and His Work with Alfred Blalock''), University of Pennsylvania Press, 1985. {{DEFAULTSORT:Blalock-Taussig shunt Cardiac surgery Congenital heart defects Pediatric surgical procedures Thoracic surgical procedures