BioNumerics is a

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combin ...

desktop software application that manages

microbiological Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells). Microbiology encompasses numerous sub-disciplines including virology, bacteriology, pro ...

data. It is developed by

Applied Maths NV Applied Maths NV, a bioMérieux company headquartered in Sint-Martens-Latem, Belgium, is a bioinformatics company developing software for the biosciences. History Applied Maths was founded in 1992 and gained worldwide recognition with the softw ...

, a

bioMérieux bioMérieux SA is a French multinational biotechnology company founded and headquartered in Marcy-l'Étoile, France, close to Lyon. bioMérieux is present in 44 countries and serves more than 160 countries through a large network of distribu ...

company.

History

BioNumerics was first released in 1998. PulseNet, a network run by the

Centers for Disease Control and Prevention The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georg ...

(CDC), uses BioNumerics to compare

pulsed field gel electrophoresis Pulsed field gel electrophoresis is a technique used for the separation of large DNA molecules by applying to a gel matrix an electric field that periodically changes direction. Historical background Standard gel electrophoresis techniques for ...

(PFGE) patterns and whole genome sequences from different bacterial strains. CaliciNet, an outbreak surveillance network for noroviruses, is another example of a network which uses BioNumerics to submit

norovirus Norovirus, sometimes referred to as the winter vomiting disease, is the most common cause of gastroenteritis. Infection is characterized by non-bloody diarrhea, vomiting, and stomach pain. Fever or headaches may also occur. Symptoms usually deve ...

sequences and basic epidemiologic information to a central database.

Features

The basis of BioNumerics is a database consisting of entries. The entries correspond to the individual organisms or samples under study and are characterized by a unique key and by a number of user-defined information fields. Each entry in a

database In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spa ...

 may be characterized by one or more experiments that can be linked easily to the entry. In BioNumerics, experiments are divided in seven classes:  fingerprints, spectra, characters, sequences, sequence read sets, trend data and matrices. Examples of BioNumerics applications are whole genome Multi Locus Sequence Typing (wgMLST), whole genome

Single Nucleotide Polymorphisms In genetics, a single-nucleotide polymorphism (SNP ; plural SNPs ) is a germline substitution of a single nucleotide at a specific position in the genome. Although certain definitions require the substitution to be present in a sufficiently larg ...

(wgSNP),

genome comparison Comparative genomics is a field of biological research in which the genomic features of different organisms are compared. The genomic features may include the DNA sequence, genes, gene order, regulatory sequences A regulatory sequence is a se ...

, identification based on MALDI-TOF Mass Spectrometry, PFGE typing,

Amplified Fragment Length Polymorphism AFLP-PCR or just AFLP is a PCR-based tool used in genetics research, DNA fingerprinting, and in the practice of genetic engineering. Developed in the early 1990s by KeyGene, AFLP uses restriction enzymes to digest genomic DNA, followed by lig ...

(AFLP) typing, sequence-based typing of viruses,

antibiotic resistance Antimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials. All classes of microbes can evolve resistance. Fungi evolve antifungal resistance. Viruses evolve antiviral resistanc ...

profiling and functional genotyping.

References

External links

Applied Maths’ official websiteScientific articles using BioNumerics
{{DEFAULTSORT:BIONUMERICS Bioinformatics software