Archibald's sign (also known as Archibald's metacarpal sign) refers to a feature in the hand characterized by a shortening of the fourth or/and fifth metacarpals when the fist is clenched.
Causes
The causes of Archibald's sign are not known; however, it has been discovered that it occurs more often in populations with certain disorders. Archibald's sign appears to be more common in individuals who have
Turners syndrome
Turner syndrome (TS), also known as 45,X, or 45,X0, is a genetic condition in which a female is partially or completely missing an X chromosome. Signs and symptoms vary among those affected. Often, a short and webbed neck, low-set ears, low hairl ...
. It also seems to be more commonly found in
pseudohypoparathyroidism
Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone. Those with the condition have a low serum calcium and high phosphate, but the parathyroid hormone level (PTH) is appropriately high (due to th ...
of Albright's hereditary osteodystrophy,
brachydactyly
Brachydactyly (Greek βραχύς = "short" plus δάκτυλος = "finger"), is a medical term which literally means "short finger". The shortness is relative to the length of other long bones and other parts of the body. Brachydactyly is an in ...
,
acrodysostosis, and occasionally with
homocystinuria
Homocystinuria or HCU is an inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited autosomal recessive trait, which means a child needs to in ...
.
See also
*
Pseudohypoparathyroidism
Pseudohypoparathyroidism is a condition associated primarily with resistance to the parathyroid hormone. Those with the condition have a low serum calcium and high phosphate, but the parathyroid hormone level (PTH) is appropriately high (due to th ...
References
External links
Archibald's metacarpal sign* An image of an individual with Archibald's sign is shown on the left hand in photo b i
this picture
Congenital disorders
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