Aloe Barbadensis
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''Aloe vera'' () is a
succulent plant In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid climates or soil conditions. The word ''succulent'' comes from the Latin word ''sucus'', meanin ...
species A species () is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can produce fertile offspring, typically by sexual reproduction. It is the basic unit of Taxonomy (biology), ...
of the
genus Genus (; : genera ) is a taxonomic rank above species and below family (taxonomy), family as used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In bino ...
''
Aloe ''Aloe'' (; also written ''Aloë'') is a genus containing over 650 species of flowering plant, flowering succulent plant, succulent plants.WFO (2022): Aloe L. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo-4000001341. Acc ...
''. It is widely distributed, and is considered an
invasive species An invasive species is an introduced species that harms its new environment. Invasive species adversely affect habitats and bioregions, causing ecological, environmental, and/or economic damage. The term can also be used for native spec ...
in many world regions. An
evergreen In botany, an evergreen is a plant which has Leaf, foliage that remains green and functional throughout the year. This contrasts with deciduous plants, which lose their foliage completely during the winter or dry season. Consisting of many diffe ...
perennial In horticulture, the term perennial ('' per-'' + '' -ennial'', "through the year") is used to differentiate a plant from shorter-lived annuals and biennials. It has thus been defined as a plant that lives more than 2 years. The term is also ...
, it originates from the
Arabian Peninsula The Arabian Peninsula (, , or , , ) or Arabia, is a peninsula in West Asia, situated north-east of Africa on the Arabian plate. At , comparable in size to India, the Arabian Peninsula is the largest peninsula in the world. Geographically, the ...
, but also grows wild in tropical, semi-tropical, and arid climates around the world. It is cultivated for commercial products, mainly as a
topical A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes ...
treatment used over centuries. The species is considered attractive for decorative purposes, and is often used indoors as a
potted plant Container gardening or pot gardening/farming is the practice of growing plants, including edible plants, exclusively in containers instead of planting them in the ground. A container in gardening is a small, enclosed and usually portable object ...
. The leaves of ''Aloe vera'' contain significant amounts of the polysaccharide gel
acemannan Acemannan is a D-isomer mucopolysaccharide in aloe vera leaves. This compound has potential immunostimulant, antiviral, antineoplastic, and gastrointestinal properties. Chemical structure and properties Acemannan's monomer is mannoacetate link ...
, which can be used for topical purposes. The leaves also contain
aloin Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 ''Aloe'' species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 spec ...
, which is a
toxic Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subst ...
compound. ''Aloe vera'' products are typically made from the gel. ''Aloe vera'' acemannan may be used in skin lotions,
cosmetics Cosmetics are substances that are intended for application to the body for cleansing, beautifying, promoting attractiveness, or altering appearance. They are mixtures of chemical compounds derived from either Natural product, natural source ...
, ointments and gels for minor burns, skin abrasions, insect bites, and windburn. Oral ingestion of aloe vera
extract An extract (essence) is a substance made by extracting a part of a raw material, often by using a solvent such as ethanol, oil or water. Extracts may be sold as tinctures or absolutes or dried and powdered. The aromatic principles of ma ...
s may cause acute abdominal pain and cramps, and
hepatitis Hepatitis is inflammation of the liver parenchyma, liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), Anorexia (symptom), poor appetite ...
if consumed chronically. It should not be used during pregnancy. Some people have
allergic reactions Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, alle ...
to aloe when used on skin.


Etymology

The genus name ''
Aloe ''Aloe'' (; also written ''Aloë'') is a genus containing over 650 species of flowering plant, flowering succulent plant, succulent plants.WFO (2022): Aloe L. Published on the Internet;http://www.worldfloraonline.org/taxon/wfo-4000001341. Acc ...
'' is derived from the
Arabic Arabic (, , or , ) is a Central Semitic languages, Central Semitic language of the Afroasiatic languages, Afroasiatic language family spoken primarily in the Arab world. The International Organization for Standardization (ISO) assigns lang ...
word ''alloeh'', meaning "bitter and shiny substance" or from
Hebrew Hebrew (; ''ʿÎbrit'') is a Northwest Semitic languages, Northwest Semitic language within the Afroasiatic languages, Afroasiatic language family. A regional dialect of the Canaanite languages, it was natively spoken by the Israelites and ...
''ahalim'', plural of ''ahal''. The
specific epithet In Taxonomy (biology), taxonomy, binomial nomenclature ("two-term naming system"), also called binary nomenclature, is a formal system of naming species of living things by giving each a name composed of two parts, both of which use Latin gramm ...
''vera'' comes from ''verus'' meaning "true" in
Latin Latin ( or ) is a classical language belonging to the Italic languages, Italic branch of the Indo-European languages. Latin was originally spoken by the Latins (Italic tribe), Latins in Latium (now known as Lazio), the lower Tiber area aroun ...
.


Common names

Common names use ''aloe'' with a region of its distribution, such as ''Chinese aloe'', ''Cape aloe'' or ''
Barbados Barbados, officially the Republic of Barbados, is an island country in the Atlantic Ocean. It is part of the Lesser Antilles of the West Indies and the easternmost island of the Caribbean region. It lies on the boundary of the South American ...
aloe''.


Taxonomy

The species has several
synonyms A synonym is a word, morpheme, or phrase that means precisely or nearly the same as another word, morpheme, or phrase in a given language. For example, in the English language, the words ''begin'', ''start'', ''commence'', and ''initiate'' are a ...
: ''Aloe barbadensis'' Mill., ''Aloe indica'' Royle, ''Aloe perfoliata'' L. var. ''vera'' and ''Aloe vulgaris'' Lam. Some literature identifies the white-spotted form of ''Aloe vera'' as ''Aloe vera'' var. ''chinensis''; and the spotted form of ''Aloe vera'' may be
conspecific Biological specificity is the tendency of a characteristic such as a behavior or a biochemical variation to occur in a particular species. Biochemist Linus Pauling stated that "Biological specificity is the set of characteristics of living organism ...
with ''A. massawana''. The species was first described by
Carl Linnaeus Carl Linnaeus (23 May 1707 – 10 January 1778), also known after ennoblement in 1761 as Carl von Linné,#Blunt, Blunt (2004), p. 171. was a Swedish biologist and physician who formalised binomial nomenclature, the modern system of naming o ...
in 1753 as ''Aloe perfoliata'' var. ''vera'', and was described again in 1768 by
Nicolaas Laurens Burman Nicolaas Laurens Burman (27 December 1734 – 11 September 1793) was a Dutch botanist. He was the son of Johannes Burman (1707–1780). He succeeded his father to the chair of botany at the Athenaeum Illustre of Amsterdam., and at the Hortus Bot ...
as ''Aloe vera'' in ''Flora Indica'' on 6 April and by
Philip Miller Philip Miller Royal Society, FRS (1691 – 18 December 1771) was an English botany, botanist and gardener of Scottish descent. Miller was chief gardener at the Chelsea Physic Garden for nearly 50 years from 1722, and wrote the highly popular ...
as ''Aloe barbadensis'' some ten days after Burman in the ''Gardener's Dictionary''. Techniques based on
DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
comparison suggest ''Aloe vera'' is relatively closely related to ''
Aloe perryi ''Aloe perryi'' is a species of plant in the genus ''Aloe''. It is endemic to the island of Socotra in Yemen, and may be known by the common name, Socotrine aloe.''Western Arabia and the Red Sea'', Naval Intelligence Division, London 2005, p. 208 ...
'', a species endemic to Yemen. Similar techniques, using
chloroplast A chloroplast () is a type of membrane-bound organelle, organelle known as a plastid that conducts photosynthesis mostly in plant cell, plant and algae, algal cells. Chloroplasts have a high concentration of chlorophyll pigments which captur ...
DNA sequence comparison and inter simple sequence repeat profiling have also suggested it is closely related to ''
Aloe forbesii ''Aloe forbesii'' is a small stemless ''Aloe'' native to Socotra, Yemen Yemen, officially the Republic of Yemen, is a country in West Asia. Located in South Arabia, southern Arabia, it borders Saudi Arabia to Saudi Arabia–Yemen border, th ...
'', ''
Aloe inermis ''Aloe inermis'' is a small, stemless Aloe native to Yemen. See also *Succulent plant In botany, succulent plants, also known as succulents, are plants with parts that are thickened, fleshy, and engorged, usually to retain water in arid climat ...
'', '' Aloe scobinifolia'', ''
Aloe sinkatana ''Aloe sinkatana'' is a small, stemless Aloe native to Sudan. The plant is sometimes confused for the more common, medicinal ''Aloe vera''. See also *Succulent plant In botany, succulent plants, also known as succulents, are plants with parts ...
'', and ''
Aloe striata ''Aloe striata'', with the common name coral aloe, is a small, stemless South African Aloe species. Distribution This species occurs quite widely over the southern parts of the Cape Floristic Region, in the Eastern Cape Province and Western Cape ...
''. With the exception of the South African species ''A. striata'', these ''Aloe'' species are native to
Socotra Socotra, locally known as Saqatri, is a Yemeni island in the Indian Ocean. Situated between the Guardafui Channel and the Arabian Sea, it lies near major shipping routes. Socotra is the largest of the six islands in the Socotra archipelago as ...
(Yemen), Somalia, and Sudan. The lack of obvious natural populations of the species has led some authors to suggest ''Aloe vera'' may be of
hybrid Hybrid may refer to: Science * Hybrid (biology), an offspring resulting from cross-breeding ** Hybrid grape, grape varieties produced by cross-breeding two ''Vitis'' species ** Hybridity, the property of a hybrid plant which is a union of two diff ...
origin.


Description

''Aloe vera'' is a stemless or very short-stemmed plant growing to tall, spreading by offsets.


Leaves

The leaves are thick and fleshy, green to grey-green, with some varieties showing white flecks on their upper and lower stem surfaces.Yates A. (2002) ''Yates Garden Guide''. Harper Collins Australia The margin of the leaf is
serrated Serration is a saw-like appearance or a row of sharp or tooth-like projections. A serrated cutting edge has many small points of contact with the material being cut. By having less contact area than a smooth blade or other edge, the applied pr ...
and has small white teeth. ''Aloe vera'' leaves contain
phytochemical Phytochemicals are naturally-occurring chemicals present in or extracted from plants. Some phytochemicals are nutrients for the plant, while others are metabolites produced to enhance plant survivability and reproduction. The fields of ext ...
s under study for possible bioactivity, such as
lignan The lignans are a large group of low molecular weight polyphenols found in plants, particularly seeds, whole grains, and vegetables. The name derives from the Latin word for "wood". Lignans are precursors to phytoestrogens. They may play a rol ...
s,
phytosterol Phytosterols are phytosteroids, similar to cholesterol, that serve as structural components of biological membranes of plants. They encompass plant sterols and stanol ester, stanols. More than 250 sterols and related compounds have been identified ...
s,
polyphenol Polyphenols () are a large family of naturally occurring phenols. They are abundant in plants and structurally diverse. Polyphenols include phenolic acids, flavonoids, tannic acid, and ellagitannin, some of which have been used historically as ...
s, acetylated
mannans Mannans are polymers containing the sugar mannose as a principal component. They are a type of polysaccharide found in hemicellulose, a major source of biomass found in higher plants such as softwoods. These polymers also typically contain two o ...
, polymannans,
anthraquinone Anthraquinone, also called anthracenedione or dioxoanthracene, is an aromatic hydrocarbon, aromatic organic compound with formula . Several isomers exist but these terms usually refer to 9,10-anthraquinone (IUPAC: 9,10-dioxoanthracene) wherein th ...
s C-
glycoside In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous important roles in living organisms. Many plants store chemicals in the form of inactive glycosides. ...
s,
anthrone Anthrone is a tricyclic aromatic ketone. It is used for a common cellulose assay and in the colorimetric determination of carbohydrates. Derivatives of anthrone are used in pharmacy as laxative. They stimulate the motion of the colon and reduce ...
s, and other anthraquinones, such as
emodin Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is an organic compound. Classified as an anthraquinone, it can be isolated from rhubarb, buckthorn, and Japanese knotweed ('' Reynoutria japonica'' syn. ''Polygonum cuspidatum''). Emodin is part ...
and various
lectin Lectins are carbohydrate-binding proteins that are highly specific for sugar Moiety (chemistry), groups that are part of other molecules, so cause agglutination (biology), agglutination of particular cells or precipitation of glycoconjugates an ...
s.


Flowers

The flowers are produced in summer on a spike up to tall, each flower being pendulous, with a yellow tubular corolla long. Random House Australia/


Roots

Like other ''Aloe'' species, ''Aloe vera'' forms
arbuscular mycorrhiza An arbuscular mycorrhiza (AM) (plural ''mycorrhizae'') is a type of mycorrhiza in which the symbiont fungus (''Arbuscular mycorrhizal fungi'', or AMF) penetrates the cortical cells of the roots of a vascular plant forming arbuscules. Arbuscul ...
, a root
symbiosis Symbiosis (Ancient Greek : living with, companionship < : together; and ''bíōsis'': living) is any type of a close and long-term biological interaction, between two organisms of different species. The two organisms, termed symbionts, can fo ...
that allows the plant better access to mineral nutrients from the soil.


Distribution

''Aloe vera'' is considered to be native only to the south-east
Arabian Peninsula The Arabian Peninsula (, , or , , ) or Arabia, is a peninsula in West Asia, situated north-east of Africa on the Arabian plate. At , comparable in size to India, the Arabian Peninsula is the largest peninsula in the world. Geographically, the ...
in the
Hajar Mountains The Hajar Mountains (, ''The Rock (geology), Rocky Mountains'' or ''The Stone Mountains'') are one of the highest mountain ranges in the Arabian Peninsula, shared between northern Oman and eastern United Arab Emirates. Also known as "Oman Mounta ...
in north-eastern
Oman Oman, officially the Sultanate of Oman, is a country located on the southeastern coast of the Arabian Peninsula in West Asia and the Middle East. It shares land borders with Saudi Arabia, the United Arab Emirates, and Yemen. Oman’s coastline ...
and eastern
U.A.E. The United Arab Emirates (UAE), or simply the Emirates, is a country in West Asia, in the Middle East, at the eastern end of the Arabian Peninsula. It is a federal elective monarchy made up of seven emirates, with Abu Dhabi serving as its ...
However, it has been widely cultivated around the world, and has become naturalized in North Africa, as well as Sudan and neighboring countries, along with the
Canary Islands The Canary Islands (; ) or Canaries are an archipelago in the Atlantic Ocean and the southernmost Autonomous communities of Spain, Autonomous Community of Spain. They are located in the northwest of Africa, with the closest point to the cont ...
,
Cape Verde Cape Verde or Cabo Verde, officially the Republic of Cabo Verde, is an island country and archipelagic state of West Africa in the central Atlantic Ocean, consisting of ten volcanic islands with a combined land area of about . These islands ...
, and
Madeira Islands Madeira ( ; ), officially the Autonomous Region of Madeira (), is an autonomous region of Portugal. It is an archipelago situated in the North Atlantic Ocean, in the region of Macaronesia, just under north of the Canary Islands, Spain, wes ...
. It has also naturalized in the
Algarve The Algarve (, , ) is the southernmost NUTS statistical regions of Portugal, NUTS II region of continental Portugal. It has an area of with 467,495 permanent inhabitants and incorporates 16 municipalities (concelho, ''concelhos'' or ''município ...
region of Portugal, and in wild areas across Spain, especially in the
region of Murcia The Region of Murcia (, ; ; ) is an Autonomous communities of Spain, autonomous community of Spain located in the southeastern part of the Iberian Peninsula, on the Mediterranean Sea, Mediterranean coast. The region is in area and had a popul ...
. The species was introduced to China and various parts of southern
Europe Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere. It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east ...
in the 17th century. It is widely naturalized elsewhere, occurring in arid, temperate, and tropical regions of temperate continents. The current distribution may be the result of cultivation.


Cultivation

''Aloe vera'' has been widely grown as an ornamental plant. The species is popular with modern gardeners as a topical
medicinal plant Medicinal plants, also called medicinal herbs, have been discovered and used in traditional medicine practices since prehistoric times. Plants synthesize hundreds of chemical compounds for various functions, including Plant defense against h ...
and for its interesting flowers, form, and succulence. This succulence enables the species to survive in areas of low natural rainfall, making it ideal for rockeries and other low water-use gardens. The species is hardy in
zones Zone, Zones or The Zone may refer to: Places Military zones * Zone, any of the divisions of France during the World War II German occupation * Zone, any of the divisions of Germany during the post-World War II Allied occupation * Korean Demilit ...
8–11, and is intolerant of heavy frost and snow. The species is relatively resistant to most insect pests, though
spider mite Spider mites are members of the family Tetranychidae, which includes about 1,200 species. They are part of the subclass Acari (mites). Spider mites generally live on the undersides of leaves of plants, where they may spin protective silk webs, a ...
s,
mealy bug Mealybugs are insects in the family Pseudococcidae, unarmored scale insects found in moist, warm habitats. Of the more than 2,000 described species, many are considered pests as they feed on plant juices of greenhouse plants, house plants and su ...
s,
scale insect Scale insects are small insects of the Order (biology), order Hemiptera, suborder Sternorrhyncha. Of dramatically variable appearance and extreme sexual dimorphism, they comprise the infraorder Coccomorpha which is considered a more convenient g ...
s, and
aphid Aphids are small sap-sucking insects in the Taxonomic rank, family Aphididae. Common names include greenfly and blackfly, although individuals within a species can vary widely in color. The group includes the fluffy white Eriosomatinae, woolly ...
species may cause a decline in plant health. This plant has gained the
Royal Horticultural Society The Royal Horticultural Society (RHS), founded in 1804 as the Horticultural Society of London, is the UK's leading gardening charity. The RHS promotes horticulture through its five gardens at Wisley (Surrey), Hyde Hall (Essex), Harlow Carr ...
's
Award of Garden Merit The Award of Garden Merit (AGM) is a long-established award for plants by the British Royal Horticultural Society (RHS). It is based on assessment of the plants' performance under UK growing conditions. It includes the full range of cultivated p ...
. In pots, the species requires well-drained, sandy potting soil, and bright, sunny conditions. Aloe plants can turn red from sunburn under too much direct sun, though gradual acclimation may help. The use of a good-quality commercial propagation mix or packaged "cacti and succulent mix" is recommended, as they allow good drainage. Terra cotta pots are preferable as they are porous. Potted plants should be allowed to completely dry before rewatering. When potted, aloes can become crowded with "pups" growing from the sides of the "mother plant". Plants that have become crowded can be divided and repotted to allow room for further growth, or the pups can be left with the mother plant. During winter, ''Aloe vera'' may become dormant, during which little moisture is required. In areas that receive frost or snow, the species is best kept indoors or in heated glasshouses. Houseplants requiring similar care include
haworthia ''Haworthia'' is a large genus of small succulent plants endemic to Southern Africa (Mozambique, Namibia, Lesotho, Eswatini and South Africa). Like aloes and gasteria they are members of the Family (biology), subfamily Asphodeloideae and they ...
and
agave ''Agave'' (; ; ) is a genus of monocots native to the arid regions of the Americas. The genus is primarily known for its succulent and xerophytic species that typically form large Rosette (botany), rosettes of strong, fleshy leaves. Many plan ...
. There is large-scale agricultural production of ''Aloe vera'' in Australia, Cuba, the Dominican Republic, China, Mexico, India, Jamaica, Kenya, Tanzania, South Africa, Spain, and the United States, with much of the output going toward the cosmetics industry.


Uses

Two substances from ''Aloe vera'' – a clear gel and its yellow
latex Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latices are found in nature, but synthetic latices are common as well. In nature, latex is found as a wikt:milky, milky fluid, which is present in 10% of all floweri ...
– are used to manufacture commercial products. Aloe gel typically is used to make
topical medication A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surface area, body surfaces such as the skin or mucous membranes to treat ailments via a large ...
s for skin conditions, such as burns, wounds, frostbite,
rash A rash is a change of the skin that affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cracke ...
es,
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...
,
cold sores A cold sore is a type of herpes infection caused by the herpes simplex virus that affects primarily the lip. Symptoms typically include a burning pain followed by small blisters or sores. The first attack may also be accompanied by fever, so ...
, and dry skin. Aloe latex is used individually or manufactured as a product with other ingredients to be ingested for relief of
constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The Human feces, stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the ...
. Aloe latex may be obtained in a dried form called ''resin'' or as "aloe dried juice". There is conflicting evidence regarding whether ''Aloe vera'' is effective as a treatment for wounds or burns. There is some evidence that topical use of aloe products might relieve symptoms of certain skin disorders, such as
psoriasis Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete b ...
,
acne Acne ( ), also known as ''acne vulgaris'', is a long-term Cutaneous condition, skin condition that occurs when Keratinocyte, dead skin cells and Sebum, oil from the skin clog hair follicles. Typical features of the condition include comedo, ...
, or
rash A rash is a change of the skin that affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cracke ...
es, but topical application may cause an
allergic reaction Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
in some people. ''Aloe vera'' gel is used commercially as an ingredient in
yogurt Yogurt (; , from , ; also spelled yoghurt, yogourt or yoghourt) is a food produced by bacterial Fermentation (food), fermentation of milk. Fermentation of sugars in the milk by these bacteria produces lactic acid, which acts on milk protein to ...
s, beverages, and some desserts, but at high or prolonged doses, ingesting aloe latex or whole leaf extract can be toxic. Use of topical aloe vera in small amounts is likely to be safe.


Topical medication and potential side effects

''Aloe vera'' may be prepared as a
lotion Lotion is a low-viscosity topical preparation intended for application to the skin. By contrast, creams and gels have higher viscosity, typically due to lower water content. Lotions are applied to external skin with bare hands, a brush, a clea ...
, gel, soap or
cosmetics Cosmetics are substances that are intended for application to the body for cleansing, beautifying, promoting attractiveness, or altering appearance. They are mixtures of chemical compounds derived from either Natural product, natural source ...
product for use on skin as a topical medication. For people with
allergies Allergies, also known as allergic diseases, are various conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include Allergic rhinitis, hay fever, Food allergy, food al ...
to ''Aloe vera'', skin reactions may include
contact dermatitis Contact dermatitis is a type of acute or chronic inflammation of the skin caused by exposure to chemical or physical agents. Symptoms of contact dermatitis can include itchy or dry skin, a red rash, bumps, blisters, or swelling. These rashes ...
with mild redness and itching, difficulty with breathing, or swelling of the face, lips, tongue, or throat.


Dietary supplement

Aloin, a compound found in the semi-liquid latex of some ''Aloe'' species, was a common ingredient in
over-the-counter Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid pres ...
(OTC)
laxative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...
products in the United States until 2002 when the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
banned it because manufacturers failed to provide the necessary safety data. ''Aloe vera'' has potential toxicity, with
side effects In medicine, a side effect is an effect of the use of a medicinal drug or other treatment, usually adverse but sometimes beneficial, that is unintended. Herbal and traditional medicines also have side effects. A drug or procedure usually used ...
occurring at some dose levels both when ingested and when applied topically. Although toxicity may be less when aloin is removed by processing, ''Aloe vera'' ingested in high amounts may induce side effects, such as
abdominal pain Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues. Since the abdomen contains most of the body's vital organs, it can be an indicator of a wide variety of diseases. Given th ...
,
diarrhea Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day. It often lasts for a few days and can result in dehydration d ...
or
hepatitis Hepatitis is inflammation of the liver parenchyma, liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), Anorexia (symptom), poor appetite ...
. Chronic ingestion of aloe (dose of 1 gram per day) may cause adverse effects, including
hematuria Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. "Gross hematuria" occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable with ...
, weight loss, and cardiac or kidney disorders. ''Aloe vera'' juice is marketed to support the health of the digestive system, but there is neither scientific evidence nor regulatory approval for this claim. The extracts and quantities typically used for such purposes are associated with toxicity in a dose-dependent way.


Traditional medicine

''Aloe vera'' is used in traditional medicine as a skin treatment. Early records of its use appear from the fourth millennium BCE. It is also written of in the ''
Juliana Anicia Codex The Vienna Dioscurides or Vienna Dioscorides is an early 6th-century Byzantine Greek illuminated manuscript of an even earlier 1st century AD work, () by Pedanius Dioscorides in Greek uncial, uncial script. It is an important and rare example of ...
'' of 512 CE.Reynolds, Tom (Ed.) (2004) ''Aloes: The genus Aloe (Medicinal and Aromatic Plants - Industrial Profiles''. CRC Press.


Commodities

''Aloe vera'' is used on
facial tissue Facial tissue and paper handkerchief refers to a class of soft, absorbent, disposable papers that are suitable for use on the face. They are disposable alternatives for cloth handkerchiefs. The terms are commonly used to refer to the type of tis ...
s where it is promoted as a moisturizer and anti-irritant to reduce chafing of the nose. Cosmetic companies commonly add sap or other derivatives from ''Aloe vera'' to products such as makeup, tissues, moisturizers, soaps, sunscreens, incense, shaving cream, or shampoos. A review of academic literature notes that its inclusion in many hygiene products is due to its "moisturizing emollient effect".


Toxicity

Orally ingested non-decolorized aloe vera leaf extract was listed by the
California Office of Environmental Health Hazard Assessment The Office of Environmental Health Hazard Assessment, commonly referred to as OEHHA (pronounced oh-EEE-ha), is a specialized department within the cabinet-level California Environmental Protection Agency (CalEPA) with responsibility for evaluati ...
among "chemicals known to the state to cause cancer or reproductive toxicity", possibly resulting from the
anthraquinone Anthraquinone, also called anthracenedione or dioxoanthracene, is an aromatic hydrocarbon, aromatic organic compound with formula . Several isomers exist but these terms usually refer to 9,10-anthraquinone (IUPAC: 9,10-dioxoanthracene) wherein th ...
s. Since 2016, aloe vera whole leaf extract is classified as a possible human carcinogen ( group 2B) by the
International Agency for Research on Cancer The International Agency for Research on Cancer (IARC; ) is an intergovernmental agency forming part of the World Health Organization of the United Nations. Its role is to conduct and coordinate research into the causes of cancer. It also cance ...
. Use of aloe vera on the skin is generally not associated with significant side effects. Oral ingestion of aloe vera is potentially toxic, and may cause
abdominal cramps Abdominal pain, also known as a stomach ache, is a symptom associated with both non-serious and serious medical issues. Since the abdomen contains most of the body's vital organs, it can be an indicator of a wide variety of diseases. Given th ...
and
diarrhea Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day. It often lasts for a few days and can result in dehydration d ...
which in turn can decrease the absorption of drugs.


Interactions with prescribed drugs

Ingested aloe products may have adverse interactions with prescription drugs, such as those used to treat
blood clot A thrombus ( thrombi) is a solid or semisolid aggregate from constituents of the blood (platelets, fibrin, red blood cells, white blood cells) within the circulatory system during life. A blood clot is the final product of the blood coagulatio ...
s,
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
,
heart disease Cardiovascular disease (CVD) is any disease involving the heart or blood vessels. CVDs constitute a class of diseases that includes: coronary artery diseases (e.g. angina pectoris, angina, myocardial infarction, heart attack), heart failure, ...
and
potassium Potassium is a chemical element; it has Symbol (chemistry), symbol K (from Neo-Latin ) and atomic number19. It is a silvery white metal that is soft enough to easily cut with a knife. Potassium metal reacts rapidly with atmospheric oxygen to ...
-lowering agents (such as
Digoxin Digoxin (better known as digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart disease, heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. ...
), and
diuretic A diuretic () is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics ...
s, among others.


Gallery

File:Aloe vera leaf showing the gel (1).JPG, Leaf and inner gel File:Aloe vera gel.jpg, Gel used for
dessert Dessert is a course (food), course that concludes a meal; the course consists of sweet foods, such as cake, biscuit, ice cream, and possibly a beverage, such as dessert wine or liqueur. Some cultures sweeten foods that are more commonly umami, ...
s File:Es Lidah Buaya.JPG, ''Es lidah buaya'', an Indonesian ''Aloe vera'' iced drink File:Gelaloevera.JPG, Juice File:Cut Aloe Vera Leaf.jpg, Cut leaf File:Aloe vera cut leaf drawing1.jpg, Diagram of leaf: 1 Cuticle, 2 Chloroplast parenchym, 3 Inner tissue,  4 Vascular bundles File:Aloe Vera Buds.jpg, Buds File:Aloe Vera flower.jpg, Flower buds File:Aloe vera flower 2.jpg, Flowers File:AloeBluhendD2.JPG, Plants of different sizes File:A potted aloe vera plant.jpg, A potted plant File:Aloe plant bud.jpg, Basal shoots (root sprouts)


References


External links

* {{DEFAULTSORT:Aloe vera
vera Vera may refer to: Names *Vera (surname), a surname (including a list of people with the name) * Vera (given name), a given name (including a list of people and fictional characters with the name) **Vera (), archbishop of the archdiocese of Tarr ...
Drought-tolerant plants Flora of the Arabian Peninsula Garden plants of Africa