Alexis Frank Hartmann Sr. (October 30, 1898 – September 6, 1964) was an American

pediatrician Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until th ...

and clinical biochemist. He is best known for adding

sodium lactate Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting lactic acid to create a compound having the formula Na ...

Ringer's solution Ringer's solution is a solution of several salts dissolved in water for the purpose of creating an isotonic solution relative to the body fluids of an animal. Ringer's solution typically contains sodium chloride, potassium chloride, calcium chlor ...

, creating what is now known as

Ringer's lactate solution Ringer's lactate solution (RL), also known as sodium lactate solution, Lactated Ringer’s, and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water. It is used for replacing flu ...

or Hartmann's solution for

intravenous infusion Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...

Early life

Hartmann was born in October 30, 1898 in

St. Louis St. Louis () is the second-largest city in Missouri, United States. It sits near the confluence of the Mississippi and the Missouri Rivers. In 2020, the city proper had a population of 301,578, while the bi-state metropolitan area, which e ...

Missouri Missouri is a U.S. state, state in the Midwestern United States, Midwestern region of the United States. Ranking List of U.S. states and territories by area, 21st in land area, it is bordered by eight states (tied for the most with Tennessee ...

. His parents were Henry Charles Hartmann, a general practitioner, and Bertha Hauck Griesedick; both were of German ancestry. He enrolled at

Washington University in St. Louis Washington University in St. Louis (WashU or WUSTL) is a private research university with its main campus in St. Louis County, and Clayton, Missouri. Founded in 1853, the university is named after George Washington. Washington University i ...

, receiving a bachelor's degree in 1919 and master's and medical degrees in 1921. While he was a medical student, he developed a new technique to test

blood sugar level Glycaemia, also known as blood sugar level, blood sugar concentration, or blood glucose level is the measure of glucose concentrated in the blood of humans or other animals. Approximately 4 grams of glucose, a simple sugar, is present in the blo ...

Career

Hartmann completed his residency in pediatrics at

St. Louis Children's Hospital St. Louis Children's Hospital is a dedicated pediatric hospital in St. Louis, Missouri, and has a primary service region covering six states. As the pediatric teaching hospital for Washington University School of Medicine, St. Louis Children's Hos ...

in 1923. He was an instructor in pediatrics at Washington University, his alma mater, and was promoted to assistant professor in 1925 then associate professor in 1927. He was promoted to a full professor in pediatrics and head of the pediatric department at Washington University in 1936. In the same year, he was appointed physician-in-chief at St. Louis Children's Hospital, and remained in the position when the hospital became racially integrated in 1950. Hartmann published 90 papers during his career. His scientific work pertained to biochemistry and problems of

metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...

, while his clinical pediatric interests included

anoxia The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or "low oxygen". The terms anoxia and hypoxia are used in various contexts: * Anoxic waters, sea water, fresh water or groundwater that are depleted of di ...

hypoglycemia Hypoglycemia, also called low blood sugar, is a fall in blood sugar to levels below normal, typically below 70 mg/dL (3.9 mmol/L). Whipple's triad is used to properly identify hypoglycemic episodes. It is defined as blood glucose be ...

nephritis Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue surrounding the glomeruli and tubules. It is one of several different types of nephropathy. Types * Glomerulonephritis is inflammation ...

nephrosis Nephrosis is any of various forms of kidney disease (nephropathy). In an old and broad sense of the term, it is any nephropathy, but in current usage the term is usually restricted to a narrower sense of nephropathy without inflammation or neopla ...

and

chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothe ...

. He was among the first doctors to use

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabol ...

to treat

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level (hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...

in infants. His best known contribution to medicine was in body electrolytes and

intravenous fluids Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...

replacement. He modified

by adding

, an alkaline substance, to treat

acidosis Acidosis is a process causing increased acidity in the blood and other body tissues (i.e., an increase in hydrogen ion concentration). If not further qualified, it usually refers to acidity of the blood plasma. The term ''acidemia'' describes ...

in children. His invention,

, became popular internationally and is commonly known as Hartmann's solution.

Personal life

Hartmann married Gertrude Krochmann, a librarian, in 1922. They had two sons: Henry Carl Hartmann, a businessman, and Alexis Frank Hartmann Jr., a pediatric

cardiologist Cardiology () is a branch of medicine that deals with disorders of the heart and the cardiovascular system. The field includes medical diagnosis and treatment of congenital heart defects, coronary artery disease, heart failure, valvular he ...

. Hartmann retired in 1964 and died on September 6 of that same year.

References

{{DEFAULTSORT:Hartmann, Alexis 1898 births 1964 deaths American pediatricians American biochemists American medical researchers Physicians from Missouri Writers from St. Louis American people of German descent Washington University School of Medicine alumni Washington University School of Medicine faculty Washington University in St. Louis alumni