An adenovirus vaccine is a
vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifi ...
against
adenovirus infection
Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. Typical symptoms range from those of a common cold, such as nasal congestion, rhinitis, and cough, to difficulty b ...
.
According to the American
CDC
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency under the Department of Health and Human Services (HHS), and is headquartered in Atlanta, ...
, "There is currently no adenovirus vaccine available to the general public.
It should not be confused with the strategy of using adenovirus as a
viral vector
A viral vector is a modified virus designed to gene delivery, deliver genetic material into cell (biology), cells. This process can be performed inside an organism or in cell culture. Viral vectors have widespread applications in basic research, ...
to develop vaccines for other
pathogen
In biology, a pathogen (, "suffering", "passion" and , "producer of"), in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a Germ theory of d ...
s, or as a general
gene carrier.
US military
It was used by the
United States military
The United States Armed Forces are the Military, military forces of the United States. U.S. United States Code, federal law names six armed forces: the United States Army, Army, United States Marine Corps, Marine Corps, United States Navy, Na ...
from 1971 to 1999, but was discontinued when the only manufacturer stopped production.
This vaccine elicited immunity to adenovirus
serotype
A serotype or serovar is a distinct variation within a species of bacteria or virus or among immune cells of different individuals. These microorganisms, viruses, or Cell (biology), cells are classified together based on their shared reactivity ...
s 4 and 7,
the serotypes most often associated with acute respiratory disease. On 16 March 2011, the
U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by
Teva Pharmaceuticals
Teva Pharmaceutical Industries Ltd. (also known as Teva Pharmaceuticals) is an Israeli multinational Pharmaceutical industry, pharmaceutical company. Teva specializes primarily in generic drugs, but other business interests include branded-drug ...
under contract to the U.S. Army. This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.
The vaccine is orally administered and consists of live (not
attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.
Package insert for Adenovirus Type 4 and Type 7 Vaccine, Live, Oral
fda.gov, accessed 9 July 2020
References
External links
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