Keratoderma is a hornlike skin condition.
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Classification
The keratodermas are classified into the following subgroups:[Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .]
Congenital
* Simple keratodermas
** Diffuse palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
s
*** Diffuse epidermolytic palmoplantar keratoderma
*** Diffuse nonepidermolytic palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cl ...
*** mal de Meleda
** Focal palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cl ...
*** Striate palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
** Punctate palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Keratosis punctata palmaris et plantaris
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Spiny keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Focal acral hyperkeratosis
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
* Complex keratodermas
** Diffuse palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Erythrokeratodermia variabilis
Erythrokeratodermia variabilis (also known as "erythrokeratodermia figurata variabilis", "keratosis extremitatum progrediens", "keratosis palmoplantaris transgrediens et progrediens",Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General ...
*** Palmoplantar keratoderma of Sybert
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Olmsted syndrome
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Naegeli–Franceschetti–Jadassohn syndrome
Naegeli–Franceschetti–Jadassohn syndrome (NFJS), also known as chromatophore nevus of Naegeli and Naegeli syndrome, is a rare autosomal dominant form of ectodermal dysplasia, characterized by reticular skin pigmentation, diminished function of ...
** Focal palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cl ...
*** Papillon–Lefèvre syndrome
Papillon–Lefèvre syndrome (PLS), also known as palmoplantar keratoderma with periodontitis, is an autosomal recessive genetic disorder caused by a deficiency in cathepsin C.
Presentation
PLS is characterized by periodontitis and palmoplantar k ...
*** Pachyonychia congenita type I
Pachyonychia congenita (often abbreviated as "PC") is a rare group of autosomal dominant skin disorders that are caused by a mutation in one of five different keratin genes. Pachyonychia congenita is often associated with thickened toenails, plant ...
*** Pachyonychia congenita type II
Pachyonychia congenita (often abbreviated as "PC") is a rare group of autosomal dominant skin disorders that are caused by a mutation in one of five different keratin genes. Pachyonychia congenita is often associated with thickened toenails, plant ...
***
*** Camisa disease
Camisa disease is the variant form of Vohwinkel syndrome, characterized by ichthyosis and normal hearing.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .
It is associated with loricrin.
It wa ...
** Ectodermal dysplasia
Ectodermal dysplasia (ED) is a group of genetic syndromes all deriving from abnormalities of the ectodermal structures.James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Sa ...
s
*** Clouston's hidrotic ectodermal dysplasia
Clouston's hidrotic ectodermal dysplasia is a medical condition caused by mutations in a connexin gene, GJB6 or connexin-30, characterized by scalp hair that is wiry, brittle, and pale, often associated with patchy alopecia.Freedberg, et al. (2 ...
*** Acrokeratotic poikiloderma
*** Dermatopathic pigmentosa reticularis
Dermatopathia pigmentosa reticularis (DPR) is a rare, autosomal dominant congenital disorder that is a form of ectodermal dysplasia. Dermatopathia pigmentosa reticularis is composed of the triad of generalizereticulate hyperpigmentation noncica ...
** Syndromic keratoderma
Keratoderma is a hornlike skin condition.
Classification
The keratodermas are classified into the following subgroups:Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .
Congenital
* Simple ker ...
s
*** Vohwinkel syndrome
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Palmoplantar keratoderma associated with esophageal cancer
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against ...
*** Palmoplantar keratoderma and spastic paraplegia
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
*** Naxos disease
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Naxos disease (also known as "diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiomyopathy" or "diffuse palmoplantar keratoderma with woolly hair and arrhythmogenic right ventricular cardiomyopathy", first des ...
*** Striate palmoplantar keratoderma, woolly hair, and left ventricular dilated cardiomyopathy
*** Keratitis-ichthyosis-deafness syndrome
*** Corneodermatosseous syndrome
Corneodermatosseous syndrome is an autosomal dominant condition with onset in infancy, characterized by corneal dystrophy, photophobia, diffuse palmoplantar keratoderma, distal onycholysis, skeletal abnormalities, with brachydactyly, short stature, ...
*** Huriez syndrome
*** Oculocutaneous tyrosinemia
Tyrosinemia type II is an autosomal recessive condition with onset between ages 2 and 4 years, when painful circumscribed calluses develop on the pressure points of the palm of the hand and sole of the foot.
Pathophysiology
Type II tyrosinemia ...
*** Cardiofaciocutaneous syndrome
Cardiofaciocutaneous (CFC) syndrome is an extremely rare genetic disorder, and is one of the RASopathies. It was first described in 1986.
It is characterized by the following:
*Distinctive facial appearance
*Unusually sparse, brittle, curly scal ...
*** Schöpf–Schulz–Passarge syndrome
Schöpf–Schulz–Passarge syndrome is an autosomal recessive condition with punctate symmetric palmoplantar keratoderma, with the keratoderma and fragility of the nails beginning around age 12.Freedberg, et al. (2003). ''Fitzpatrick's Dermatolog ...
Acquired
* Acquired keratodermas
** AIDS-associated keratoderma
** Arsenical keratoses
An arsenical keratosis is a growth of keratin on the skin caused by arsenic,Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . which occurs naturally in the earth's crust and is widely distributed ...
** Calluses
A callus is an area of thickened and sometimes hardened skin that forms as a response to repeated friction, pressure, or other irritation. Since repeated contact is required, calluses are most often found on the feet and hands, but they may o ...
** Climacteric keratoderma
Climacteric may refer to:
* Climacteric (human), the time in most women's lives when menstrual periods stop permanently
* Climacteric (botany), a stage of fruit ripening
* ''Climacteric'' (journal), a journal published by Informa Healthcare
* Cli ...
** Clavi (Corns)
** Eczema
Dermatitis is inflammation of the skin, typically characterized by itchiness, redness and a rash. In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened. The area of skin involved can v ...
** Human papillomavirus
Human papillomavirus infection (HPV infection) is caused by a DNA virus from the '' Papillomaviridae'' family. Many HPV infections cause no symptoms and 90% resolve spontaneously within two years. In some cases, an HPV infection persists and r ...
** Keratoderma blenorrhagicum
Keratoderma is a hornlike skin condition.
Classification
The keratodermas are classified into the following subgroups:Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. .
Congenital
* Simple ker ...
** Lichen planus
Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, f ...
** Norwegian scabies
Scabies (; also sometimes known as the seven-year itch) is a contagious skin infestation by the mite '' Sarcoptes scabiei''. The most common symptoms are severe itchiness and a pimple-like rash. Occasionally, tiny burrows may appear on the ...
** Paraneoplastic keratoderma
Paraneoplastic keratoderma is a cutaneous condition characterized by a hornlike skin texture associated with an internal malignancy.
See also
* Keratoderma
* List of cutaneous conditions
Many skin conditions affect the human integumentary ...
** Psoriasis
Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by raised areas of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small, localized patches to complet ...
** Reactive arthritis
Reactive arthritis, also known as Reiter's syndrome, is a form of inflammatory arthritis that develops in response to an infection in another part of the body (cross-reactivity). Coming into contact with bacteria and developing an infection can ...
** Secondary syphilis
Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...
** Tinea pedis
Dermatophytosis, also known as ringworm, is a fungal infection of the skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation ...
** Sézary syndrome
** Tuberculosis verrucosa cutis
** Drug-induced keratoderma
Drug-induced keratoderma is a cutaneous condition characterized by a hornlike skin texture.
See also
* Keratoderma
* List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the e ...
Treatment
Keratolytic products containing, urea, salicylic, glycolic and lactic acids are helpful. One proprietary cream (Pedifix Cracks and Calluses Cream) is efficacious.
See also
* Palmoplantar keratoderma
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Autosomal recessive, dominant, X-linked, and acquired forms have all been described.
Types
Cli ...
* Skin lesion
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of thi ...
* List of cutaneous conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier agai ...
*
References
External links
Papulosquamous hyperkeratotic cutaneous conditions
{{Cutaneous-condition-stub