Adiponectin receptor 1 (AdipoR1) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
which in humans is encoded by the ''ADIPOR1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
It is a member of the
progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.
Structure
Similar to
G protein-coupled receptors (GPCRs), AdipoR1 also possesses 7
transmembrane domains. However, AdipoR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic
N-terminus, extracellular
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein
Proteins are large biomolecules and macromolecules that comp ...
) and does not associate with
G protein
G proteins, also known as guanine nucleotide-binding proteins, are a Protein family, family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell (biology), ...
s.
Function
The
adiponectin receptors, AdipoR1 and
AdipoR2, serve as receptors for globular and full-length
adiponectin and mediate increased
AMPK and
PPAR-α ligand activities, as well as
fatty acid
In chemistry, in particular in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated and unsaturated compounds#Organic chemistry, saturated or unsaturated. Most naturally occurring fatty acids have an ...
oxidation and glucose uptake by adiponectin.
In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called
Ordinary_researchers.
[University of Tokyo to investigate data manipulation charges against six prominent research groups](_blank)
ScienceInsider, Dennis Normile, Sep 20, 2016
Ligands
Agonists
Peptide
*
Adiponectin
* ADP-355
* ADP-399
Non-peptide
*
AdipoRon
* (−)-Arctigenin
*
Arctiin
*
Gramine
*
Matairesinol
Antagonists
Peptide
* ADP-400
See also
*
Adiponectin receptor
*
Adiponectin receptor 2
References
External links
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Further reading
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7TM receptors
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