ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular

protease A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes (increases reaction rate or "speeds up") proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the form ...

enzymes. 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the

extracellular matrix In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide struc ...

. They have been demonstrated to have important roles in connective tissue organization,

coagulation Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanis ...

, inflammation,

arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some ...

, angiogenesis and cell migration. Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of

ADAMTS13 ADAMTS13 (''a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13'')—also known as ''von Willebrand factor-cleaving protease'' (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand facto ...

. Like

ADAMs Adams may refer to: * For persons, see Adams (surname) Places United States *Adams, California *Adams, California, former name of Corte Madera, California *Adams, Decatur County, Indiana *Adams, Kentucky *Adams, Massachusetts, a New England town ...

, the name of the ADAMTS family refers to its disintegrin and

metalloproteinase A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myoge ...

activity, and in the case of ADAMTS, the presence of a thrombospondin motif.

ADAMTS family members

* ADAMTS1 *

ADAMTS2 A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme that in humans is encoded by the ''ADAMTS2'' gene. Gene The ADAMTS2 gene is located on the long (q) ...

* ADAMTS3 * ADAMTS4 * ADAMTS5 (=ADAMTS11) *

ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 is a protein that in humans is encoded by the ADAMTS6 gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredit ...

* ADAMTS7 * ADAMTS8 (or METH-2), an

antiangiogenic An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical d ...

METH-2 silencing and promoter hypermethylation in NSCLC
/ref> * ADAMTS9 * ADAMTS10 * ADAMTS12 *

* ADAMTS14 * ADAMTS15 * ADAMTS16 * ADAMTS17 * ADAMTS18 * ADAMTS19 * ADAMTS20

References

{{Portal bar, Biology, border=no EC 3.4.24 Human proteins

ADAMTS family members

See also

References