In molecular biology, the ABM domain is a

protein domain In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest. Each domain forms a compact folded three-dimensional structure. Many proteins consist o ...

that is found in

monooxygenase Monooxygenases are enzymes that incorporate one hydroxyl group (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of dioxygen are reduced to one hydroxyl group and one H2O molecule by the concomitant oxidation ...

s involved in the biosynthesis of several

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, ...

s by ''Streptomyces'' species, which can carry out

oxygenation Oxygenation may refer to: * Oxygenation (environmental), a measurement of dissolved oxygen concentration in soil or water * Oxygen saturation (medicine), the process by which concentrations of oxygen increase within a tissue * Water oxygenation, t ...

without the assistance of any of the prosthetic groups, metal

ion An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conven ...

s or

cofactors Cofactor may also refer to: * Cofactor (biochemistry), a substance that needs to be present in addition to an enzyme for a certain reaction to be catalysed * A domain parameter in elliptic curve cryptography, defined as the ratio between the orde ...

normally associated with

activation Activation, in chemistry and biology, is the process whereby something is prepared or excited for a subsequent reaction. Chemistry In chemistry, "activation" refers to the reversible transition of a molecule into a nearly identical chemical ...

molecular oxygen There are several known allotropy, allotropes of oxygen. The most familiar is oxygen, molecular oxygen (O2), present at significant levels in Atmosphere of Earth, Earth's atmosphere and also known as dioxygen or triplet oxygen. Another is the hig ...

. The structure of ActVA-Orf6 monooxygenase from ''Streptomyces coelicolor'', which is involved in actinorhodin biosynthesis, reveals a dimeric alpha+beta barrel topology. There is also a conserved

histidine Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the ...

that is likely to be an active site residue. In the ''S. coelicolor'' protein SCO1909 this domain occurs as a

repeat Repeat may refer to: * Rerun, a rebroadcast of an episode of a radio or television program * Repeated sequence (DNA), a pattern of nucleic acid (DNA or RNA) that occurs in multiple copies throughout the genome ** CRISPR * The smallest rectangle ...

References

{{InterPro content, IPR007138 Protein domains