A-366,833 is a drug developed by
Abbott, which acts as an agonist at neural
nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are Receptor (biochemistry), receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the c ...
s selective for the
α4β2 subtype, and has been researched for use as an
analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...
, although it has not passed
clinical trials
Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...
. Its structure has a nicotinonitrile (
3-cyanopyridine) core bound through C5 to the N6 of (1''R'',5''S'')-3,6-diazabicyclo
.2.0eptane.
References
Analgesics
Azetidines
Nicotinic agonists
Nitriles
3-Aminopyridines
Pyrrolidines
Stimulants
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