A-366,833 is a drug developed by Abbott, which acts as an agonist at neural

nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are Receptor (biochemistry), receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the c ...

s selective for the α4β2 subtype, and has been researched for use as an

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

, although it has not passed

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

. Its structure has a nicotinonitrile ( 3-cyanopyridine) core bound through C5 to the N6 of (1''R'',5''S'')-3,6-diazabicyclo .2.0eptane.

References

Analgesics Azetidines Nicotinic agonists Nitriles 3-Aminopyridines Pyrrolidines Stimulants {{analgesic-stub