7-Methylguanosine (m
7G) is a modified
purine
Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted puri ...
nucleoside. It is a
methylated version of
guanosine and when found in human urine, it may be a
biomarker
In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, ...
of some types of cancer. In the
RNA
Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...
s, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also participates in the formation of
5'-cap that stabilizes
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein.
mRNA is ...
and prevents its degradation by 5'
exonucleases.
See also
*
m7G(5')pppN diphosphatase
*
METTL1
*
Messenger RNA decapping
*
23S rRNA (guanine2445-N2)-methyltransferase
*
16S rRNA (guanine527-N7)-methyltransferase
*
N1-Methylguanosine (m
1G)
References
External links
Metabocard for 7-Methylguanosine (HMDB01107) Human Metabolome Database, University of Alberta
Nucleosides
Purines
Hydroxymethyl compounds
Biomarkers
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