6-Phosphogluconolactone is an intermediate in the
pentose phosphate pathway
The pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt) is a metabolic pathway parallel to glycolysis. It generates NADPH and pentoses (five-carbon sugars) as well as ribose 5-ph ...
(PPP).
In the PPP pathway, it is produced from
glucose-6-phosphate by
glucose-6-phosphate dehydrogenase
Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) () is a cytosolic enzyme that catalysis, catalyzes the chemical reaction
: Glucose 6-phosphate, D-glucose 6-phosphate + NADP+ + 6-Phosphogluconolactone, 6-phospho-D-glucono-1,5-lactone + NADPH ...
. It is then converted to
6-Phosphogluconic acid by
6-phosphogluconolactonase.
See also
*
Lactone
References
Organophosphates
Pentose phosphate pathway
Delta-lactones
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