4'-Methoxy-α-pyrrolidinopropiophenone (MOPPP) is a

stimulant Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...

designer drug A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...

of the pyrrolidinophenone class. It has the potential to produce

euphoria Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and da ...

, an effect shared with other classical stimulants.

Recreational use

MOPPP use is infrequent when compared to other

amphetamines Substituted amphetamines, or simply amphetamines, are a chemical class, class of compounds based upon the amphetamine structure; it includes all derivative (chemistry), derivative compounds which are formed by replacing, or substitution reacti ...

s used recreationally, such as

meth Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational or performance-enhancing drug and less commonly as a second-line treatment for attention deficit hyperactivity ...

cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...

, or

speed In kinematics, the speed (commonly referred to as ''v'') of an object is the magnitude of the change of its position over time or the magnitude of the change of its position per unit of time; it is thus a non-negative scalar quantity. Intro ...

. It first arose as a

in Germany in the late 1990s and early 2000s, along with a number of other derivatives but never gained the international popularity that other drugs in its family of pyrrolidinophenone derivatives had (such as α-PPP and

MDPV Methylenedioxypyrovalerone (abbreviated MDPV, and also called monkey dust) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ing ...

). While the recent trend of selling stimulants through false labeling (i.e., ''

bath salts Bath salts are water-soluble, pulverized minerals that are added to water to be used for bathing. It is said that these salts improve cleaning, enhance the enjoyment of bathing, and serve as a vehicle for cosmetic agents. Bath salts have been de ...

'') has gained notoriety, using

as its main ingredient, this has not been the case with MOPPP, despite its similar potential for abuse.

Chemistry

MOPPP is structurally related to α-PPP in the same way that PMA is related to

amphetamine Amphetamine (contracted from Alpha and beta carbon, alpha-methylphenethylamine, methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, an ...

: a

methoxy In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula . On a benzene ring, the Hammett equation classifies a methoxy substituent at the ''para'' position a ...

group has been added to the 4-position on the

phenyl In organic chemistry, the phenyl group, or phenyl ring, is a cyclic group of atoms with the formula , and is often represented by the symbol Ph (archaically φ) or Ø. The phenyl group is closely related to benzene and can be viewed as a benzene ...

ring.

Metabolism

MOPPP appears to be metabolized within the liver chiefly by the enzyme

CYP2D6 Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the ''CYP2D6'' gene. ''CYP2D6'' is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra. CYP2 ...

References

{{DEFAULTSORT:Methoxy-A-Pyrrolidinopropiophenone, 4'- Designer drugs Methoxyphenethylamines Stimulants Pyrrolidinophenones 4-Methoxyphenyl compounds

Recreational use

Chemistry

Metabolism

See also

References