2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 (Wake Forest-23, named after the university where it was first created) is a
cocaine
Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
analogue. It is several hundred times more potent than cocaine at being a
serotonin-norepinephrine-dopamine reuptake inhibitor.
As can be seen on
PubMed
PubMed is an openly accessible, free database which includes primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institute ...
, these acyl substituted phenyltropanes are highly potent
MAT
A mat is a hard or soft floor covering that generally is placed on a floor or other flat surface. Mats serve a range of purposes including:
* serving to clean items passed over it, such as a doormat, which removes dirt from the soles of shoe ...
inhibitors and also have a very long
half-life Half-life is a mathematical and scientific description of exponential or gradual decay.
Half-life, half life or halflife may also refer to:
Film
* Half-Life (film), ''Half-Life'' (film), a 2008 independent film by Jennifer Phang
* ''Half Life: ...
, spanning perhaps at least a few days; as the half-life of the dopamine transporter in rats was found to be 2–3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life),
it may be that WF-23 largely or mostly binds to its transporters until they are degraded.
See also
*
HDEP-28
HDEP-28 or ethylnaphthidate is a stimulant drug of the piperidine and substituted naphthylaminopropane, naphthylaminopropane groups, closely related to ethylphenidate, but with the benzene ring replaced by naphthalene. It is even more closely re ...
*
HDMP-28
HDMP-28 or methylnaphthidate is a stimulant drug of the piperidine and naphthylaminopropane groups, closely related to methylphenidate (Ritalin), but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, wit ...
*
List of cocaine analogues
This is a list of cocaine analogues. A cocaine analogue is an (usually) artificial construct of a novel chemical compound from (often the starting point of natural) cocaine's molecular structure, with the result product sufficiently similar to co ...
References
Further reading
*
{{DEFAULTSORT:Propanoyl 3 beta 2 Naphthyl Tropane
Tropanes
Serotonin–norepinephrine–dopamine reuptake inhibitors
Stimulants
2-Naphthyl compounds
Ketones