2,4,5-Trihydroxymethamphetamine (THMA or THM) is a
neurotoxin
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological insultsSpencer 2000 that can adversely affect function in both developing and matur ...
and a metabolite of
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for recreational purposes. The desired ...
. It has structural similarity to the dopamine neurotoxin
6-hydroxydopamine
Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain.
The main use for ...
, and produces lasting serotonin deficits when administered centrally.
See also
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2,4,5-Trihydroxyamphetamine (THA)
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3,4-Dihydroxyamphetamine
α-Methyldopamine (α-Me-DA), also known as 3,4-dihydroxyamphetamine (3,4-DHA or HHA), is a research chemical of the catecholamine and amphetamine chemical classes. Its bis- glutathionyl metabolite is slightly neurotoxic when directly injecte ...
(HHA; α-methyldopamine)
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3,4-Dihydroxymethamphetamine (HHMA; α-methylepinine)
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4-Hydroxy-3-methoxyamphetamine (HMA)
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4-Hydroxy-3-methoxymethamphetamine
4-Hydroxy-3-methoxymethamphetamine (HMMA) is an active metabolite An active metabolite is an active form of a drug after it has been processed by the body.
Metabolites of drugs
An active metabolite results when a drug is metabolized by the body ...
(HMMA)
References
Human pathological metabolites
Methamphetamines
Monoaminergic neurotoxins
Recreational drug metabolites
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