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(''S'')-2,3-Oxidosqualene ((''S'')-2,3-epoxysqualene) is an intermediate in the synthesis of the cell membrane
sterol A sterol is any organic compound with a Skeletal formula, skeleton closely related to Cholestanol, cholestan-3-ol. The simplest sterol is gonan-3-ol, which has a formula of , and is derived from that of gonane by replacement of a hydrogen atom on ...
precursors lanosterol and cycloartenol, as well as saponins. It is formed when squalene is oxidized by the enzyme squalene monooxygenase. 2,3-Oxidosqualene is the substrate of various oxidosqualene cyclases, including lanosterol synthase, which produces lanosterol, a precursor to
cholesterol Cholesterol is the principal sterol of all higher animals, distributed in body Tissue (biology), tissues, especially the brain and spinal cord, and in Animal fat, animal fats and oils. Cholesterol is biosynthesis, biosynthesized by all anima ...
. The stereoisomer (''R'')-2,3-oxidosqualene is an inhibitor of lanosterol synthase.


References


External links


Oxidosqualene cyclase, PDB December 2007 Molecule of the Month
{{DEFAULTSORT:Oxidosqualene, 2,3- Epoxides Triterpenes Polyenes