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ORTHO-MDMA, also known as 2,3-methylenedioxymethamphetamine (2,3-MDMA), is a positional isomer of the recreational drug 3,4-MDMA (commonly known as Ecstasy or Molly). It is a
monoamine transporter Monoamine transporters (MATs) are proteins that function as integral Cell membrane, plasma-membrane Neurotransmitter transporter, transporters to regulate concentrations of extracellular monoamine neurotransmitters. The three major classes are se ...
(MAT)
substrate Substrate may refer to: Physical layers *Substrate (biology), the natural environment in which an organism lives, or the surface or medium on which an organism grows or is attached ** Substrate (aquatic environment), the earthy material that exi ...
and
inhibitor Inhibitor or inhibition may refer to: Biology * Enzyme inhibitor, a substance that binds to an enzyme and decreases the enzyme's activity * Reuptake inhibitor, a substance that increases neurotransmission by blocking the reuptake of a neurotransmi ...
similarly to 3,4-MDMA. However, while showing similar potency at the
norepinephrine transporter The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family 6 member 2 (SLC6A2) gene. NET is a monoamine transporter and is responsible for the sodium ...
(NET), 2,3-MDMA is less potent at the
serotonin transporter The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. SERT is a type of monoamine transporter protein t ...
(SERT). 2,3-MDMA has not been encountered as a recreational or
designer drug A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. ...
.


See also

* 2,3-Methylenedioxyamphetamine (2,3-MDA) * 1-Naphthylmethcathinone (AMAPN)


References


External links


2,3-MDMA , explore , PiHKAL·info
Methamphetamines Methylenedioxyphenethylamines Monoamine releasing agents {{Psychoactive-stub