The alpha-1D adrenergic receptor (α
1D adrenoreceptor), also known as ADRA1D, is an
alpha-1 adrenergic receptor
alpha-1 (α1) adrenergic are G protein-coupled receptors (GPCRs) associated with the Gq alpha subunit, Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α1A-adrenergic, α1A-, α1B ...
, and also denotes the human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
encoding it.
Receptor
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
Gene
This gene encodes alpha-1D-adrenergic receptor. Similar to
alpha-1B-adrenergic receptor gene, this gene comprises 2
exons
An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing. The term ''exon'' refers to both the DNA sequence within a gene and to the corresponding sequence i ...
and a single
intron
An intron is any nucleotide sequence within a gene that is not expressed or operative in the final RNA product. The word ''intron'' is derived from the term ''intragenic region'', i.e., a region inside a gene."The notion of the cistron .e., gen ...
that interrupts the coding region.
Ligands
Many
α1 receptor ligands are non-selective for receptor subtypes.
; Antagonists
* A-315456
*
BMY 7378 (also
α2C antagonist)
*
Domesticine
* Cyclazosin (slight α
1C selectivity)
*
Tamsulosin (roughly equal affinity for
α1A)
See also
*
Adrenergic receptor
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like b ...
References
Further reading
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External links
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Adrenergic receptors
{{transmembranereceptor-stub