α-Ethylmescaline (AEM or 3,4,5-trimethoxy-α-ethylphenethylamine) is a lesser-known
psychedelic drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluc ...
. It is an
analog
Analog or analogue may refer to:
Computing and electronics
* Analog signal, in which information is encoded in a continuous variable
** Analog device, an apparatus that operates on analog signals
*** Analog electronics, circuits which use analog ...
of
mescaline
Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...
. AEM was first synthesized by
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...
. In his book ''
PiHKAL
''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act ...
'', the minimum dosage is listed as 220 mg, and the duration unknown.
[AEM Entry in ''PiHKAL''](_blank)
/ref> AEM produces few to no effects. Very little data exists about the pharmacological properties, metabolism, and toxicity of AEM.
Derivatives
Shulgin never synthesized further α position-extended mescaline analogues, such as α-propylmescaline (APM) or α-butylmescaline (ABM), as the inactivity of AEM as a psychedelic discouraged him.head-twitch response
The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...
, a behavioral proxy of psychedelic effects, in rodents, and hence may be non-hallucinogenic as well.
See also
* Substituted mescaline analogue
A substituted mescaline analogue, also known as a scaline and typically but not always a 4-substituted 3,5-dimethoxyphenethylamine, is an analogue of the phenethylamine serotonergic psychedelic mescaline (3,4,5-trimethoxyphenethylamine).
Other ...
* α-Methylmescaline (3,4,5-TMA)
* Ariadne (drug)
References
External links
AEM Entry at ''PiHKAL''·info
3C (psychedelics)
Scalines
{{Psychoactive-stub